Title:
METHOD OF DETECTING RICIN, KIT AND SENSOR CHIP FOR DETECTING RICIN
Document Type and Number:
WIPO Patent Application WO/2007/015377
Kind Code:
A1
Abstract:
A method of detecting ricin comprising the steps of (1) detecting a test compound
by bringing the test compound into contact with a detection substrate 1 on which
a compound represented by the general formula (I) is immobilized; (I) (2) detecting
the test compound by bringing the test compound into contact with a detection
substrate 2 on which a compound represented by the general formula (II) is immobilized;
(II) (3) (a) assuming that when the compound is not detected in the detection step
1, ricin 60 is not contained in the test compound; (b) assuming that when the compound
is detected in the detection step 1 and is not detected in the detection step 2,
ricin 60 is contained in the test compound; and (c) assuming that when the compound
is detected in both detection steps 1 and 2, ricin 120 is contained in the test compound.
Inventors:
OHGA KOJI (JP)
UZAWA HIROTAKA (JP)
SETO YASUO (JP)
OHSAWA HAYAHISA (JP)
UZAWA HIROTAKA (JP)
SETO YASUO (JP)
OHSAWA HAYAHISA (JP)
Application Number:
PCT/JP2006/314378
Publication Date:
February 08, 2007
Filing Date:
July 20, 2006
Export Citation:
Assignee:
NAT INST OF ADVANCED IND SCIEN (JP)
JP NAT RES INST OF POLICE SCIE (JP)
OHGA KOJI (JP)
UZAWA HIROTAKA (JP)
SETO YASUO (JP)
OHSAWA HAYAHISA (JP)
JP NAT RES INST OF POLICE SCIE (JP)
OHGA KOJI (JP)
UZAWA HIROTAKA (JP)
SETO YASUO (JP)
OHSAWA HAYAHISA (JP)
International Classes:
G01N33/53; G01N33/553; G01N33/566; G01N33/543
Domestic Patent References:
| WO2005075493A1 | 2005-08-18 |
Other References:
STINE R. ET AL.: "Comparison of glycosphingolipids and antibodies as receptor molecules for ricin detection", ANAL. CHEM., vol. 77, 1 May 2005 (2005-05-01), pages 2882 - 2888, XP003007837
NARANG U. ET AL.: "Fiber optic-based biosensor for ricin", BIOSENSORS & BIOELECTRONICS, vol. 12, no. 9-10, 1997, pages 937 - 945, XP003007838
PUU G.: "An approach for analysis of protein toxins based on thin films of lipid mixtures in an optical biosensor", ANAL. CHEM., vol. 73, 2001, pages 72 - 79, XP003007839
GUSTAFSON I.: "Investigating the interaction of the toxin ricin and its B-chain with immobilized glycolipids in supported phospholipid membranes by surface plasmon resonance", COLLOIDS AND SURFACES B: BIOINTERFACES, vol. 30, 2003, pages 13 - 24, XP003007840
O'BRIEN T. ET AL.: "The development of immunoassays to four biological threat agents in a bidiffractive grating biosensor", BIOSENSORS & BIOELECTRONICS, vol. 14, 2000, pages 815 - 828, XP003007841
ANDERSON G.P. ET AL.: "Multi-analyte interrogation using the first optic biosensor", BIOSENSORS & BIOELECTRONICS, vol. 14, 2000, pages 771 - 777, XP003007842
NARANG U. ET AL.: "Fiber optic-based biosensor for ricin", BIOSENSORS & BIOELECTRONICS, vol. 12, no. 9-10, 1997, pages 937 - 945, XP003007838
PUU G.: "An approach for analysis of protein toxins based on thin films of lipid mixtures in an optical biosensor", ANAL. CHEM., vol. 73, 2001, pages 72 - 79, XP003007839
GUSTAFSON I.: "Investigating the interaction of the toxin ricin and its B-chain with immobilized glycolipids in supported phospholipid membranes by surface plasmon resonance", COLLOIDS AND SURFACES B: BIOINTERFACES, vol. 30, 2003, pages 13 - 24, XP003007840
O'BRIEN T. ET AL.: "The development of immunoassays to four biological threat agents in a bidiffractive grating biosensor", BIOSENSORS & BIOELECTRONICS, vol. 14, 2000, pages 815 - 828, XP003007841
ANDERSON G.P. ET AL.: "Multi-analyte interrogation using the first optic biosensor", BIOSENSORS & BIOELECTRONICS, vol. 14, 2000, pages 771 - 777, XP003007842
Attorney, Agent or Firm:
SHIMIZU, Hatsushi et al. (1-1-1 Oroshi-mach, Tsuchiura-shi Ibaraki 47, JP)
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