Title:
METHOD FOR DETECTION OF CANCER STEM CELL, AND THERAPEUTIC AGENT OR RECURRENCE-PREVENTING AGENT FOR CANCER
Document Type and Number:
WIPO Patent Application WO/2011/105551
Kind Code:
A1
Abstract:
A functional molecule involved in the regulation of cancer stem cells is newly identified. Thus, disclosed are: a technique for detecting cancer stem cells accurately; and a technique for inducing the apoptosis of cancer stem cells to completely cure cancer. CD13 is involved in the regulation of an active oxygen species removal pathway in a cancer stem cell, and is therefore a molecule essential to the maintenance of cancer stem cells. Therefore, cancer stem cells can be detected accurately using CD13 as an indicator. Further, the radical treatment of cancer (particularly liver cancer and gastrointestinal cancer) can be achieved using a CD13 inhibitor and an anti-cancer agent or a radiation therapy in combination.
Inventors:
MORI MASAKI (JP)
HARAGUCHI NAOTSUGU (JP)
ISHII HIDESHI (JP)
HARAGUCHI NAOTSUGU (JP)
ISHII HIDESHI (JP)
Application Number:
PCT/JP2011/054287
Publication Date:
September 01, 2011
Filing Date:
February 25, 2011
Export Citation:
Assignee:
UNIV OSAKA (JP)
MORI MASAKI (JP)
HARAGUCHI NAOTSUGU (JP)
ISHII HIDESHI (JP)
MORI MASAKI (JP)
HARAGUCHI NAOTSUGU (JP)
ISHII HIDESHI (JP)
International Classes:
A61K45/06; A61K31/198; A61K31/351; A61K31/513; A61K39/395; A61P35/00; C12Q1/02; G01N33/574
Other References:
ABE F. ET AL: "ENHANCEMENT OF ANTITUMOR EFFECT OF CYTOTOXIC AGENTS BY BESTATIN", THE JOURNAL OF ANTIBIOTICS, vol. 38, no. 3, March 1985 (1985-03-01), pages 411 - 414
FUMINORI ABE ET AL.: "Rat Kangan AH66 Hika Ishoku Shuyo ni Taisuru Bestatin to Bleomycin no Heiyo Koka", JAPANESE JOURNAL OF ANTIBIOTICS, vol. 37, no. 4, April 1984 (1984-04-01), pages 589 - 592
YAMASHITA M. ET AL: "Involvement of aminopeptidase N in enhanced chemosensitivity to paclitaxel in ovarian carcinoma in vitro and in vivo", INTERNATIONAL JOURNAL OF CANCER, vol. 120, no. 10, 15 May 2007 (2007-05-15), pages 2243 - 2250
AOZUKA Y. ET AL: "Anti-tumor angiogenesis effect of aminopeptidase inhibitor bestatin against B16-BL6 melanoma cells orthotopically implanted into syngeneic mice", CANCER LETTERS, vol. 216, no. 1, 8 December 2004 (2004-12-08), pages 35 - 42
FLORIAN S. ET AL: "Detection of molecular targets on the surface of CD34+/CD38- stem cells in various myeloid malignancies", LEUKEMIA & LYMPHOMA, vol. 47, no. 2, February 2006 (2006-02-01), pages 207 - 222
YAMAZAKI H. ET AL: "CD90 and CD110 correlate with cancer stem cell potentials in human T-acute lymphoblastic leukemia cells", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, vol. 383, no. 2, 29 May 2009 (2009-05-29), pages 172 - 177
HIROFUMI YAMAMOTO ET AL.: "Cancer Stem Cells in Gastrointestinal Carcinomas", BIOTHERAPY, vol. 23, no. 5, September 2009 (2009-09-01), pages 386 - 392
ROCKEN C. ET AL: "Canalicular immunostaining of aminopeptidase N (CD13) as a diagnostic marker for hepatocellular carcinoma", JOURNAL OF CLINICAL PATHOLOGY, vol. 58, no. 10, October 2005 (2005-10-01), pages 1069 - 1075
KEHLEN A. ET AL: "Biological significance of aminopeptidase N/CD13 in thyroid carcinomas", CANCER RESEARCH, vol. 63, no. 23, 1 December 2003 (2003-12-01), pages 8500 - 8506
HARAGUCHI N. ET AL: "CD13 is a therapeutic target in human liver cancer stem cells", THE JOURNAL OF CLINICAL INVESTIGATION, vol. 120, no. 9, 1 September 2010 (2010-09-01), pages 3326 - 3339
FUMINORI ABE ET AL.: "Rat Kangan AH66 Hika Ishoku Shuyo ni Taisuru Bestatin to Bleomycin no Heiyo Koka", JAPANESE JOURNAL OF ANTIBIOTICS, vol. 37, no. 4, April 1984 (1984-04-01), pages 589 - 592
YAMASHITA M. ET AL: "Involvement of aminopeptidase N in enhanced chemosensitivity to paclitaxel in ovarian carcinoma in vitro and in vivo", INTERNATIONAL JOURNAL OF CANCER, vol. 120, no. 10, 15 May 2007 (2007-05-15), pages 2243 - 2250
AOZUKA Y. ET AL: "Anti-tumor angiogenesis effect of aminopeptidase inhibitor bestatin against B16-BL6 melanoma cells orthotopically implanted into syngeneic mice", CANCER LETTERS, vol. 216, no. 1, 8 December 2004 (2004-12-08), pages 35 - 42
FLORIAN S. ET AL: "Detection of molecular targets on the surface of CD34+/CD38- stem cells in various myeloid malignancies", LEUKEMIA & LYMPHOMA, vol. 47, no. 2, February 2006 (2006-02-01), pages 207 - 222
YAMAZAKI H. ET AL: "CD90 and CD110 correlate with cancer stem cell potentials in human T-acute lymphoblastic leukemia cells", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, vol. 383, no. 2, 29 May 2009 (2009-05-29), pages 172 - 177
HIROFUMI YAMAMOTO ET AL.: "Cancer Stem Cells in Gastrointestinal Carcinomas", BIOTHERAPY, vol. 23, no. 5, September 2009 (2009-09-01), pages 386 - 392
ROCKEN C. ET AL: "Canalicular immunostaining of aminopeptidase N (CD13) as a diagnostic marker for hepatocellular carcinoma", JOURNAL OF CLINICAL PATHOLOGY, vol. 58, no. 10, October 2005 (2005-10-01), pages 1069 - 1075
KEHLEN A. ET AL: "Biological significance of aminopeptidase N/CD13 in thyroid carcinomas", CANCER RESEARCH, vol. 63, no. 23, 1 December 2003 (2003-12-01), pages 8500 - 8506
HARAGUCHI N. ET AL: "CD13 is a therapeutic target in human liver cancer stem cells", THE JOURNAL OF CLINICAL INVESTIGATION, vol. 120, no. 9, 1 September 2010 (2010-09-01), pages 3326 - 3339
Attorney, Agent or Firm:
SAEGUSA & PARTNERS (JP)
Patent business corporation 3 Edakuni [Hajime] patent firm (JP)
Patent business corporation 3 Edakuni [Hajime] patent firm (JP)
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