Title:
METHOD FOR DETERMINING THE EFFICACY OF A LUNG CANCER TREATMENT COMPRSING AN ANTI-PD-L1 ANTAGONIST AND AN ANTI-TIGIT ANTAGONIST ANTIBODY
Document Type and Number:
WIPO Patent Application WO/2023/240058
Kind Code:
A3
Abstract:
The present invention relates to prognostic and therapeutic methods for the treatment of cancer (e.g., lung cancer, e.g., non-small cell lung cancer (NSCLC)) using expression levels of tumor-associated macrophage (TAM) and regulatory T cell (Treg) genes. In particular, the invention provides methods for patient selection and treatment.
Inventors:
GUAN XIANGNAN (US)
NABET BARZIN (US)
PATIL NAMRATA (US)
NABET BARZIN (US)
PATIL NAMRATA (US)
Application Number:
PCT/US2023/067965
Publication Date:
January 18, 2024
Filing Date:
June 06, 2023
Export Citation:
Assignee:
GENENTECH INC (US)
International Classes:
G01N33/574; C12Q1/6886
Domestic Patent References:
| WO2019165434A1 | 2019-08-29 | |||
| WO2022112198A1 | 2022-06-02 |
Foreign References:
| US20210325394A1 | 2021-10-21 |
Other References:
CHO BYOUNG CHUL ET AL: "Tiragolumab plus atezolizumab versus placebo plus atezolizumab as a first-line treatment for PD-L1-selected non-small-cell lung cancer (CITYSCAPE): primary and follow-up analyses of a randomised, double-blind, phase 2 study", THE LANCET ONCOLOGY, ELSEVIER, AMSTERDAM, NL, vol. 23, no. 6, 13 May 2022 (2022-05-13), pages 781 - 792, XP087080207, ISSN: 1470-2045, [retrieved on 20220513], DOI: 10.1016/S1470-2045(22)00226-1
SPIEGEL D R ET AL: "P77.04 PROPEL: A Phase 1/2 Trial of Bempegaldesleukin (NKTR-214) Plus Pembrolizumab in Lung Cancer and other Advanced Solid Tumors", JOURNAL OF THORACIC ONCOLOGY, vol. 16, no. 3, suppl., 1 March 2021 (2021-03-01), pages S636 - S637, XP055952438, DOI: 10.1016/j.jtho.2021.01.1162
SPIEGEL D R ET AL: "P77.04 PROPEL: A Phase 1/2 Trial of Bempegaldesleukin (NKTR-214) Plus Pembrolizumab in Lung Cancer and other Advanced Solid Tumors", JOURNAL OF THORACIC ONCOLOGY, vol. 16, no. 3, suppl., 1 March 2021 (2021-03-01), pages S636 - S637, XP055952438, DOI: 10.1016/j.jtho.2021.01.1162
Attorney, Agent or Firm:
TAKARA, Thomas, J. et al. (US)
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