Title:
METHOD FOR DETERMINING FREE COPPER
Document Type and Number:
WIPO Patent Application WO/2014/181215
Kind Code:
A3
Abstract:
The present invention relates to a new method for the determination of 'free' copper concentration in serum, i.e. the portion of serum copper not structurally bound to ceruloplasmin. The present invention also refers to a method with a high degree of sensitivity and precision for the determination of free copper in serum samples of patients with Alzheimer's disease.
Inventors:
COLABUFO NICOLA ANTONIO (IT)
BERARDI FRANCESCO (IT)
LEOPOLDO MARCELLO (IT)
PERRONE ROBERTO (IT)
SQUITTI ROSANNA (IT)
BERARDI FRANCESCO (IT)
LEOPOLDO MARCELLO (IT)
PERRONE ROBERTO (IT)
SQUITTI ROSANNA (IT)
Application Number:
PCT/IB2014/061079
Publication Date:
December 30, 2015
Filing Date:
April 29, 2014
Export Citation:
Assignee:
CANOX4DRUG S P A (IT)
International Classes:
G01N31/22; C07D311/04; C07D311/10; C07D405/12; C09K11/06; G01N21/25; G01N21/64; G01N21/77; G01N33/50; G01N33/52; G01N33/84
Domestic Patent References:
| WO2014071973A1 | 2014-05-15 |
Foreign References:
| KR20110068259A | 2011-06-22 |
Other References:
DENISE BOHRER ET AL: "Comparison of ultrafiltration and solid phase extraction for the separation of free and protein-bound serum copper for the Wilson's disease diagnosis", CLINICA CHIMICA ACTA, vol. 345, no. 1-2, 1 July 2004 (2004-07-01), pages 113 - 121, XP055095129, ISSN: 0009-8981, DOI: 10.1016/j.cccn.2004.03.001
HYO SUNG JUNG ET AL: "Coumarin-Derived Cu 2+ -Selective Fluorescence Sensor: Synthesis, Mechanisms, and Applications in Living Cells", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, vol. 131, no. 5, 11 February 2009 (2009-02-11), pages 2008 - 2012, XP055063275, ISSN: 0002-7863, DOI: 10.1021/ja808611d
P. J. TWOMEY: "Relationship between Serum Copper, Ceruloplasmin, and Non-Ceruloplasmin-Bound Copper in Routine Clinical Practice", CLINICAL CHEMISTRY, vol. 51, no. 8, 1 August 2005 (2005-08-01), pages 1558 - 1559, XP055095131, ISSN: 0009-9147, DOI: 10.1373/clinchem.2005.052688
HYO SUNG JUNG ET AL: "Coumarin-Derived Cu 2+ -Selective Fluorescence Sensor: Synthesis, Mechanisms, and Applications in Living Cells", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, vol. 131, no. 5, 11 February 2009 (2009-02-11), pages 2008 - 2012, XP055063275, ISSN: 0002-7863, DOI: 10.1021/ja808611d
P. J. TWOMEY: "Relationship between Serum Copper, Ceruloplasmin, and Non-Ceruloplasmin-Bound Copper in Routine Clinical Practice", CLINICAL CHEMISTRY, vol. 51, no. 8, 1 August 2005 (2005-08-01), pages 1558 - 1559, XP055095131, ISSN: 0009-9147, DOI: 10.1373/clinchem.2005.052688
Attorney, Agent or Firm:
GERMINARIO, Claudio et al. (Piazza di Pietra 39, Roma, IT)
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