Title:
METHOD FOR DETERMINING AND/OR GUESSING MECHANISM OF ACTION OF COMPOUND IN LIVING ORGANISM
Document Type and Number:
WIPO Patent Application WO/2023/182324
Kind Code:
A1
Abstract:
Disclosed are: a method for determining and/or guessing a mechanism of action of a compound in a living organism, the method involving analyzing the activity of a nerve cell under the presence of a compound of which a mechanism of action is known and a compound of which a mechanism of action is unknown, and, by comparing the analyzed results, determining and/or guessing the mechanism of action of the compound of which a mechanism of action is unknown in a living organism; and a method for screening an antiepileptic medicine, the method involving analyzing the activities of a nerve cell under the presence of a test material and a compound of which an antiepileptic action is known, and by comparing the analysis results, selecting the test material as a candidate material of the antiepileptic medicine when the test material has the same mechanism of action as the compound.
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Inventors:
TANAKA MASAKI (JP)
SAKAGUCHI RICHI (JP)
NAKAMURA SAKI (JP)
IHA HIROYUKI (JP)
SAKAGUCHI RICHI (JP)
NAKAMURA SAKI (JP)
IHA HIROYUKI (JP)
Application Number:
PCT/JP2023/011090
Publication Date:
September 28, 2023
Filing Date:
March 22, 2023
Export Citation:
Assignee:
OTSUKA PHARMA CO LTD (JP)
International Classes:
C12Q1/02; C12M1/34; G01N21/64; G01N33/15; G01N33/50
Foreign References:
| JP2020052865A | 2020-04-02 | |||
| JP2012516687A | 2012-07-26 |
Other References:
PACICO NATHALIE, MINGORANCE-LE MEUR ANA: "New In Vitro Phenotypic Assay for Epilepsy: Fluorescent Measurement of Synchronized Neuronal Calcium Oscillations", PLOS ONE, vol. 9, no. 1, pages e84755, XP093095194, DOI: 10.1371/journal.pone.0084755
Attorney, Agent or Firm:
SAEGUSA & PARTNERS (JP)
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