Title:
METHOD FOR DETERMINING IF ORIGIN OF BIOLOGICAL SAMPLE IS FROM LIVER TISSUE
Document Type and Number:
WIPO Patent Application WO/2021/071164
Kind Code:
A1
Abstract:
The present invention relates to a method for determining whether or not a biological sample of unknown origin originates from a liver tissue and a composition comprising a liver tissue-specific DNA methylation marker for performing the method. The liver tissue-specific methylation marker can determine with excellent accuracy if the origin of a biological sample is from a liver tissue because normal liver tissues and liver cancer tissues are high in methylation level while tissues other than liver tissues are low in methylation level.
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Inventors:
KIM YOUNG JOON (KR)
KIM DA WON (KR)
HA JEONG SIL (KR)
KIM DA WON (KR)
HA JEONG SIL (KR)
Application Number:
PCT/KR2020/013290
Publication Date:
April 15, 2021
Filing Date:
September 29, 2020
Export Citation:
Assignee:
LEPIDYNE CO LTD (KR)
International Classes:
C12Q1/6881
Foreign References:
| KR20170071724A | 2017-06-26 | |||
| US20180274039A1 | 2018-09-27 | |||
| KR102103885B1 | 2020-04-24 |
Other References:
GAI WANXIA, JI LU, LAM W K JACKY, SUN KUN, JIANG PEIYONG, CHAN ANTHONY W H, WONG JOHN, LAI PAUL B S, NG SIMON S M, MA BRIGETTE B Y: "CONCLUSIONS", CLINICAL CHEMISTRY, OXFORD UNIVERSITY PRESS, US, vol. 64, no. 8, 1 August 2018 (2018-08-01), US, pages 1239 - 1249, XP055800473, ISSN: 0009-9147, DOI: 10.1373/clinchem.2018.290304
RONI LEHMANN-WERMAN, JUDITH MAGENHEIM, JOSHUA MOSS, DANIEL NEIMAN, OFRI ABRAHAM, SHEINA PIYANZIN, HAI ZEMMOUR, ILANA FOX, TALYA DO: "Monitoring liver damage using hepatocyte-specific methylation markers in cell-free circulating DNA", JCI INSIGHT, vol. 3, no. 12, 21 June 2018 (2018-06-21), XP055511731, DOI: 10.1172/jci.insight.120687
DATABASE NUCLEOTIDE GENBANK; ANONYMOUS: "Human DNA sequence from clone RP11-426E5 on chromosome 10, complete sequence", XP055800476, retrieved from FASTA
DATABASE NUCLEOTIDE GENBANK; ANONYMOUS: "Homo sapiens 3 BAC RP13-616I3 (Roswell Park Cancer Institute Human BAC Ibrary) complete sequence", XP055800481, retrieved from FASTA
JOSEPH SAMBROOK ET AL.: "A LaboratoryManual", 2001, COLD SPRING HARBOR LABORATORY PRESS, article "MolecularCloning"
M.L.M. ANDERSON: "NucleicAcid Hybridization", 1999, SPRINGER-VERLAG NEW YORK INC.
RONI LEHMANN-WERMAN, JUDITH MAGENHEIM, JOSHUA MOSS, DANIEL NEIMAN, OFRI ABRAHAM, SHEINA PIYANZIN, HAI ZEMMOUR, ILANA FOX, TALYA DO: "Monitoring liver damage using hepatocyte-specific methylation markers in cell-free circulating DNA", JCI INSIGHT, vol. 3, no. 12, 21 June 2018 (2018-06-21), XP055511731, DOI: 10.1172/jci.insight.120687
DATABASE NUCLEOTIDE GENBANK; ANONYMOUS: "Human DNA sequence from clone RP11-426E5 on chromosome 10, complete sequence", XP055800476, retrieved from FASTA
DATABASE NUCLEOTIDE GENBANK; ANONYMOUS: "Homo sapiens 3 BAC RP13-616I3 (Roswell Park Cancer Institute Human BAC Ibrary) complete sequence", XP055800481, retrieved from FASTA
JOSEPH SAMBROOK ET AL.: "A LaboratoryManual", 2001, COLD SPRING HARBOR LABORATORY PRESS, article "MolecularCloning"
M.L.M. ANDERSON: "NucleicAcid Hybridization", 1999, SPRINGER-VERLAG NEW YORK INC.
Attorney, Agent or Firm:
DANA PATENT LAW FIRM (KR)
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