Title:
METHOD FOR DETERMINING THE INFLUENCE OF NON-PHYSIOLOGICAL COMPOUNDS THE DERIVATIVES AND DECOMPOSITION PRODUCTS THEREOF ON ORGANISMS ORGANS AND CELLS
Document Type and Number:
WIPO Patent Application WO2003050535
Kind Code:
A3
Abstract:
The invention relates to a method for determining reversible or irreversible physiological side-effects of a substance whereby said method comprises the following steps: a) preparation of a sample treated with the substance, preferably comprising a single cell or several cells in a cell structure or an organ, b) determination of cellular and/or sub-cellular patterns from regional localisations and co-localisations of at least two different molecules, in particular proteins, RNA molecules, or DNA segments, in at least one sub-population of cells, c) comparison of the pattern obtained in step b) with patterns from an untreated control sample and d) determination of a physiological side-effect of the substance by means of various patterns for a treated sample in comparison with an untreated sample.
Inventors:
HENCO KARSTEN (DE)
JESSEN TIMM (DE)
KUPPER JUERGEN (DE)
GREINER ERICH (DE)
GUENTHER ROLF (DE)
JESSEN TIMM (DE)
KUPPER JUERGEN (DE)
GREINER ERICH (DE)
GUENTHER ROLF (DE)
Application Number:
PCT/EP2002/013996
Publication Date:
December 18, 2003
Filing Date:
December 10, 2002
Export Citation:
Assignee:
EVOTEC AG (DE)
EVOTEC TECHNOLOGIES GMBH (DE)
HENCO KARSTEN (DE)
JESSEN TIMM (DE)
KUPPER JUERGEN (DE)
GREINER ERICH (DE)
GUENTHER ROLF (DE)
EVOTEC TECHNOLOGIES GMBH (DE)
HENCO KARSTEN (DE)
JESSEN TIMM (DE)
KUPPER JUERGEN (DE)
GREINER ERICH (DE)
GUENTHER ROLF (DE)
International Classes:
G01N33/50; (IPC1-7): G01N33/50; C12Q1/02
Domestic Patent References:
| WO2000077517A1 | 2000-12-21 | |||
| WO1998045704A2 | 1998-10-15 |
Foreign References:
| US6150173A | 2000-11-21 |
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