Title:
METHOD FOR DETERMINING THE SUSCEPTIBILITY OF A SUBJECT TO INFECTION
Document Type and Number:
WIPO Patent Application WO2004034061
Kind Code:
A3
Abstract:
The present invention relates to diagnosis of neutropenia and to methods for determining susceptibility to infection. The invention also relates to methods for treating neutropenia and treating and/or preventing infections. The inventors have shown that a reduction in the levels of LL-37 in the saliva and neutrophils results in an increased susceptibility to periodontal infections caused mainly by bacteria from the normal oral flora. The present invention provides a method for determining the susceptibility of a subject to infection, which method comprises: i) providing a sample from said subject; ii) detecting any LL-37 present in said sample; iii) optionally comparing the level of LL-37 in said sample to a control. sample; and iv) determining the susceptibility of said subject to infection, wherein no LL-37 or a low level of LL-37 indicates that said subject is susceptible to infection.
Inventors:
BOMAN HANS (SE)
ANDERSSON MATS (SE)
PUETSEP KATRIN (SE)
CARLSSON GOERAN (SE)
ANDERSSON MATS (SE)
PUETSEP KATRIN (SE)
CARLSSON GOERAN (SE)
Application Number:
PCT/EP2003/011240
Publication Date:
May 21, 2004
Filing Date:
October 10, 2003
Export Citation:
Assignee:
MABTECH AB (SE)
BOMAN HANS (SE)
ANDERSSON MATS (SE)
PUETSEP KATRIN (SE)
CARLSSON GOERAN (SE)
BOMAN HANS (SE)
ANDERSSON MATS (SE)
PUETSEP KATRIN (SE)
CARLSSON GOERAN (SE)
International Classes:
A61K38/17; G01N33/68; (IPC1-7): G01N33/68; A61K38/00
Domestic Patent References:
| WO2002060468A2 | 2002-08-08 | |||
| WO1999011663A1 | 1999-03-11 | |||
| WO1999013080A1 | 1999-03-18 |
Foreign References:
| JP2001288105A | 2001-10-16 | |||
| US20030175755A1 | 2003-09-18 | |||
| DE10028725A1 | 2001-12-13 | |||
| US6159936A | 2000-12-12 | |||
| US5972594A | 1999-10-26 |
Other References:
GOMBART ADRIAN F ET AL: "Neutrophil-specific granule deficiency: Homozygous recessive inheritance of a frameshift mutation in the gene encoding transcription factor CCAAT/enhancer binding protein-epsilon", BLOOD, vol. 97, no. 9, 1 May 2001 (2001-05-01), pages 2561 - 2567, XP002275342, ISSN: 0006-4971
WEINBERG A ET AL: "Epithelial antimicrobial peptides: Review and significance for oral applications", CRITICAL REVIEWS IN ORAL BIOLOGY AND MEDICINE, vol. 9, no. 4, November 1998 (1998-11-01), pages 399 - 414, XP000972953, ISSN: 1045-4411
NIZET V ET AL: "Innate antimicrobial peptide protects the skin from invasive bacterial infection", NATURE 22 NOV 2001 UNITED KINGDOM, vol. 414, no. 6862, 22 November 2001 (2001-11-22), pages 454 - 457, XP002275343, ISSN: 0028-0836
ZETTERSTRÖM ROLF: "Kostmann disease--infantile genetic agranulocytosis: historical views and new aspects.", ACTA PAEDIATRICA (OSLO, NORWAY: 1992) NORWAY 2002, vol. 91, no. 12, 2002, pages 1279 - 1281, XP008028913, ISSN: 0803-5253
PUTSEP KATRIN ET AL: "Deficiency of antibacterial peptides in patients with morbus Kostmann: An observation study", LANCET (NORTH AMERICAN EDITION), vol. 360, no. 9340, 12 October 2002 (2002-10-12), pages 1144 - 1149, XP002275344, ISSN: 0099-5355
ONG PECK Y ET AL: "Endogenous antimicrobial peptides and skin infections in atopic dermatitis", NEW ENGLAND JOURNAL OF MEDICINE, vol. 347, no. 15, 10 October 2002 (2002-10-10), pages 1151 - 1160, XP008028910, ISSN: 0028-4793
JUREVIC R J ET AL: "Single-nucleotide polymorphisms and haplotype analysis in [beta]-defensin genes in different ethnic populations", GENETIC TESTING 2002 UNITED STATES, vol. 6, no. 4, 2002, pages 261 - 269, XP002969563, ISSN: 1090-6576
LEHRER ROBERT I ET AL: "Cathelicidins: a family of endogenous antimicrobial peptides.", CURRENT OPINION IN HEMATOLOGY. UNITED STATES JAN 2002, vol. 9, no. 1, January 2002 (2002-01-01), pages 18 - 22, XP008028914, ISSN: 1065-6251
LEVY OFER: "Antimicrobial proteins and peptides of blood: Templates for novel antimicrobial agents", BLOOD, vol. 96, no. 8, 15 October 2000 (2000-10-15), pages 2664 - 2672, XP002224605, ISSN: 0006-4971
WEINBERG A ET AL: "Epithelial antimicrobial peptides: Review and significance for oral applications", CRITICAL REVIEWS IN ORAL BIOLOGY AND MEDICINE, vol. 9, no. 4, November 1998 (1998-11-01), pages 399 - 414, XP000972953, ISSN: 1045-4411
NIZET V ET AL: "Innate antimicrobial peptide protects the skin from invasive bacterial infection", NATURE 22 NOV 2001 UNITED KINGDOM, vol. 414, no. 6862, 22 November 2001 (2001-11-22), pages 454 - 457, XP002275343, ISSN: 0028-0836
ZETTERSTRÖM ROLF: "Kostmann disease--infantile genetic agranulocytosis: historical views and new aspects.", ACTA PAEDIATRICA (OSLO, NORWAY: 1992) NORWAY 2002, vol. 91, no. 12, 2002, pages 1279 - 1281, XP008028913, ISSN: 0803-5253
PUTSEP KATRIN ET AL: "Deficiency of antibacterial peptides in patients with morbus Kostmann: An observation study", LANCET (NORTH AMERICAN EDITION), vol. 360, no. 9340, 12 October 2002 (2002-10-12), pages 1144 - 1149, XP002275344, ISSN: 0099-5355
ONG PECK Y ET AL: "Endogenous antimicrobial peptides and skin infections in atopic dermatitis", NEW ENGLAND JOURNAL OF MEDICINE, vol. 347, no. 15, 10 October 2002 (2002-10-10), pages 1151 - 1160, XP008028910, ISSN: 0028-4793
JUREVIC R J ET AL: "Single-nucleotide polymorphisms and haplotype analysis in [beta]-defensin genes in different ethnic populations", GENETIC TESTING 2002 UNITED STATES, vol. 6, no. 4, 2002, pages 261 - 269, XP002969563, ISSN: 1090-6576
LEHRER ROBERT I ET AL: "Cathelicidins: a family of endogenous antimicrobial peptides.", CURRENT OPINION IN HEMATOLOGY. UNITED STATES JAN 2002, vol. 9, no. 1, January 2002 (2002-01-01), pages 18 - 22, XP008028914, ISSN: 1065-6251
LEVY OFER: "Antimicrobial proteins and peptides of blood: Templates for novel antimicrobial agents", BLOOD, vol. 96, no. 8, 15 October 2000 (2000-10-15), pages 2664 - 2672, XP002224605, ISSN: 0006-4971
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