Title:
METHOD AND DEVICE FOR EVALUATING ORAL ABSORBABILITY OF DRUG
Document Type and Number:
WIPO Patent Application WO/2021/215039
Kind Code:
A1
Abstract:
A method for evaluating the oral absorbability of a drug according to the present invention, said method comprising putting the drug or a drug-containing preparation into a simulated gastrointestinal fluid, allowing the drug in the simulated gastrointestinal fluid to permeate into a simulated blood through a drug-permeable membrane, and then measuring the drug concentration in the simulated gastrointestinal fluid and/or the simulated blood to thereby evaluate the oral absorbability of the drug or the drug in the preparation after oral administration, characterized in that the conditions of the simulated gastrointestinal fluid are changed with time so as to mimic the conditions in the stomach and then the conditions in the small intestine and, at the same time, the contact area between the simulated gastrointestinal fluid and the drug-permeable membrane is enlarged with time. According to this method, the absorbability of a drug into the blood circulating through the whole body, after the oral administration of the drug or a drug-containing preparation to a human being, can be evaluated at a high accuracy.
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Inventors:
YAMASHITA SHINJI (JP)
KATAOKA MAKOTO (JP)
HIGASHINO HARUKI (JP)
TAKAGI TOSHIHIDE (JP)
KATAOKA MAKOTO (JP)
HIGASHINO HARUKI (JP)
TAKAGI TOSHIHIDE (JP)
Application Number:
PCT/JP2020/044362
Publication Date:
October 28, 2021
Filing Date:
November 27, 2020
Export Citation:
Assignee:
JOSHO GAKUEN EDUCATIONAL FOUND (JP)
International Classes:
G01N33/15
Foreign References:
| JP6386193B2 | 2018-09-05 | |||
| JP2012037512A | 2012-02-23 | |||
| US5807115A | 1998-09-15 |
Attorney, Agent or Firm:
TADA Eiko et al. (JP)
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