Title:
METHOD AND DEVICE FOR MEASURING TDP-43 IN BIOLOGICAL SAMPLE
Document Type and Number:
WIPO Patent Application WO/2022/190737
Kind Code:
A1
Abstract:
The present invention relates to a method for measuring TDP-43 in a biological sample. The non-capture beads used in the method do not bind with immunocomplexes of TDP-43, capture antibody, and detection antibody in the biological sample. Immunocomplexes form on capture beads. The detection antibody and/or the capture antibody recognizes TDP-43 specifically, and the epitope of the capture antibody and the epitope of the detection antibody are different.
Inventors:
TOKUDA TAKAHIKO (JP)
TATEBE HARUTSUGU (JP)
TATEBE HARUTSUGU (JP)
Application Number:
PCT/JP2022/004776
Publication Date:
September 15, 2022
Filing Date:
February 08, 2022
Export Citation:
Assignee:
NATIONAL INSTITUTES FOR QUANTUM SCIENCE AND TECH (JP)
International Classes:
C12N15/12; G01N33/53; G01N33/543
Domestic Patent References:
| WO2017170986A1 | 2017-10-05 | |||
| WO2011109364A2 | 2011-09-09 |
Foreign References:
| JP2019027952A | 2019-02-21 | |||
| JP2015505665A | 2015-02-26 | |||
| JP2019513752A | 2019-05-30 | |||
| US20110212848A1 | 2011-09-01 |
Other References:
TAKAHIKO TOKUDA, ET AL.: "Quantification of TDP-43 in cerebrospinal fluid and blood and its clinical usefulness", SAISHIN IGAKU [=LATEST MEDICINE], SAISHIN IGAKU-SHA, OSAKA, JP, vol. 65, no. 7, 1 July 2010 (2010-07-01), JP , pages 98 (1642) - 103 (1647), XP009539491, ISSN: 0370-8241
DENG HAN-XIANG, CHEN WENJIE, HONG SEONG-TSHOOL, BOYCOTT KYM M., GORRIE GEORGE H., SIDDIQUE NAILAH, YANG YI, FECTO FAISAL, SHI YONG: "Mutations in UBQLN2 cause dominant X-linked juvenile and adult-onset ALS and ALS/dementia", NATURE, NATURE PUBLISHING GROUP UK, LONDON, vol. 477, no. 7363, 1 September 2011 (2011-09-01), London, pages 211 - 215, XP055966363, ISSN: 0028-0836, DOI: 10.1038/nature10353
SUZUKI HIROAKI, SHIBAGAKI YOSHIO, HATTORI SEISUKE, MATSUOKA MASAAKI: "Nuclear TDP-43 causes neuronal toxicity by escaping from the inhibitory regulation by hnRNPs", HUMAN MOLECULAR GENETICS, OXFORD UNIVERSITY PRESS, GB, vol. 24, no. 6, 15 March 2015 (2015-03-15), GB , pages 1513 - 1527, XP055966364, ISSN: 0964-6906, DOI: 10.1093/hmg/ddu563
SERAFíN VERóNICA; RAZZINO CLAUDIA A.; GAMELLA MARIA; PEDRERO MARíA; POVEDANO ELOY; MONTERO-CALLE ANA; BARDERAS RODR: "Disposable immunoplatforms for the simultaneous determination of biomarkers for neurodegenerative disorders using poly(amidoamine) dendrimer/gold nanoparticle nanocomposite", ANALYTICAL AND BIOANALYTICAL CHEMISTRY, SPRINGER BERLIN HEIDELBERG, BERLIN/HEIDELBERG, vol. 413, no. 3, 1 January 1900 (1900-01-01), Berlin/Heidelberg, pages 799 - 811, XP037336739, ISSN: 1618-2642, DOI: 10.1007/s00216-020-02724-3
KASAI T ET AL., ACTA NEUROPATHOL, vol. 117, no. 1, 2009, pages 55 - 62
KASAI T ET AL., ANN CLIN TRANSL NEUROL, vol. 6, no. 12, 2019, pages 2489 - 2502
FOULDS P ET AL., ACTA NEUROPATHOL, vol. 116, no. 2, 2008, pages 141 - 6
"NCBI", Database accession no. NP_031401
DENG HAN-XIANG, CHEN WENJIE, HONG SEONG-TSHOOL, BOYCOTT KYM M., GORRIE GEORGE H., SIDDIQUE NAILAH, YANG YI, FECTO FAISAL, SHI YONG: "Mutations in UBQLN2 cause dominant X-linked juvenile and adult-onset ALS and ALS/dementia", NATURE, NATURE PUBLISHING GROUP UK, LONDON, vol. 477, no. 7363, 1 September 2011 (2011-09-01), London, pages 211 - 215, XP055966363, ISSN: 0028-0836, DOI: 10.1038/nature10353
SUZUKI HIROAKI, SHIBAGAKI YOSHIO, HATTORI SEISUKE, MATSUOKA MASAAKI: "Nuclear TDP-43 causes neuronal toxicity by escaping from the inhibitory regulation by hnRNPs", HUMAN MOLECULAR GENETICS, OXFORD UNIVERSITY PRESS, GB, vol. 24, no. 6, 15 March 2015 (2015-03-15), GB , pages 1513 - 1527, XP055966364, ISSN: 0964-6906, DOI: 10.1093/hmg/ddu563
SERAFíN VERóNICA; RAZZINO CLAUDIA A.; GAMELLA MARIA; PEDRERO MARíA; POVEDANO ELOY; MONTERO-CALLE ANA; BARDERAS RODR: "Disposable immunoplatforms for the simultaneous determination of biomarkers for neurodegenerative disorders using poly(amidoamine) dendrimer/gold nanoparticle nanocomposite", ANALYTICAL AND BIOANALYTICAL CHEMISTRY, SPRINGER BERLIN HEIDELBERG, BERLIN/HEIDELBERG, vol. 413, no. 3, 1 January 1900 (1900-01-01), Berlin/Heidelberg, pages 799 - 811, XP037336739, ISSN: 1618-2642, DOI: 10.1007/s00216-020-02724-3
KASAI T ET AL., ACTA NEUROPATHOL, vol. 117, no. 1, 2009, pages 55 - 62
KASAI T ET AL., ANN CLIN TRANSL NEUROL, vol. 6, no. 12, 2019, pages 2489 - 2502
FOULDS P ET AL., ACTA NEUROPATHOL, vol. 116, no. 2, 2008, pages 141 - 6
"NCBI", Database accession no. NP_031401
Attorney, Agent or Firm:
HARAKENZO WORLD PATENT & TRADEMARK (JP)
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