Title:
METHOD OF DIAGNOSING ALZHEIMER'S DISEASE
Document Type and Number:
WIPO Patent Application WO/1995/005395
Kind Code:
A1
Abstract:
Substances useful for diagnosing Alzheimer's disease and studying the cause and therapy of the same, such as a protein having the following characteristics and an antibody produced by the protein of fragments thereof, a method of diagnosing Alzheimer's disease, and a kit therefor: (1) molecular weight: 40 kD as determined by sodium dodecyl sulfate-polyacrylamide gel electrophoresis; (2) isoelectric point: pI = 8.2; (3) amino acid sequence (A) starting with the N-terminus till the 15th residue, wherein Xaa represents an unidentified amino acid residue.
Inventors:
SUGAYA KIMINOBU (JP)
MARUSAWA HIROSHI (JP)
MARUSAWA HIROSHI (JP)
Application Number:
PCT/JP1994/001359
Publication Date:
February 23, 1995
Filing Date:
August 17, 1994
Export Citation:
Assignee:
FUJISAWA PHARMACEUTICAL CO (JP)
SUGAYA KIMINOBU (JP)
MARUSAWA HIROSHI (JP)
SUGAYA KIMINOBU (JP)
MARUSAWA HIROSHI (JP)
International Classes:
C07K14/47; G01N33/68; (IPC1-7): C07K14/47; G01N33/53
Domestic Patent References:
| WO1992001464A1 | 1992-02-06 |
Foreign References:
| JPH0418100A | 1992-01-22 | |||
| US4839283A | 1989-06-13 |
Other References:
GENOMICS, Vol. 2, No. 2, 1988, JIA-JU BAO, "Molecular Structure and Sequence Homology of a Gene Related to alpha1-Antitrypsin in the Human Genome", pages 165-173.
J. MOL. BIOL., Vol. 218, No. 3, 1991, U. BAUMANN, "Crystal Structure of Cleaved Human alpha1-Antichymotrypsin at 2.7A Resolution and Its Comparison With Other Serpins", pages 595-606.
ADV. EXP. MED. BIOL., Vol. 281, 1990, DOMINIC W. CHUNG, "Nucleotide Sequences of the Three Genes Coding for Human Fibrinogen", pages 39-48.
BIOCHEMISTRY, Vol. 24, No. 8, 1985, MARK W. RIXON, "Nucleotide Sequence of the Gene for the gamma Chain of Human Fibrinogen", pages 2077-2086.
J. MOL. BIOL., Vol. 218, No. 3, 1991, U. BAUMANN, "Crystal Structure of Cleaved Human alpha1-Antichymotrypsin at 2.7A Resolution and Its Comparison With Other Serpins", pages 595-606.
ADV. EXP. MED. BIOL., Vol. 281, 1990, DOMINIC W. CHUNG, "Nucleotide Sequences of the Three Genes Coding for Human Fibrinogen", pages 39-48.
BIOCHEMISTRY, Vol. 24, No. 8, 1985, MARK W. RIXON, "Nucleotide Sequence of the Gene for the gamma Chain of Human Fibrinogen", pages 2077-2086.
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