Title:
METHOD FOR DIAGNOSING CANINE CANCER
Document Type and Number:
WIPO Patent Application WO/2023/013568
Kind Code:
A1
Abstract:
Provided is a method for diagnosing canine cancer by causing a computer to make a diagnosis on the basis of a result of gene expression analysis using canine microRNA. This method is for diagnosing canine cancer and comprises a diagnosis step for acquiring a result of gene expression analysis of microRNA extracted from body fluid of a diagnosis target canine, determining the gene expression level of a specific microRNA by using the result, and making a diagnosis regarding the degree of risk of the diagnosis target canine being diseased with a specific cancerous disease by using said gene expression level as a diagnosis criteria. The method is characterized in that the specific microRNA is a microRNA in which a significant difference was observed in the gene expression level between healthy canines and canines diseased with the specific cancerous disease, on the basis of the result of gene expression analysis of microRNA extracted from the body fluid of the canine.
Inventors:
OCHIYA TAKAHIRO (JP)
ITOH HIROSHI (JP)
TSUCHIYA REIKO (JP)
ITOH HIROSHI (JP)
TSUCHIYA REIKO (JP)
Application Number:
PCT/JP2022/029420
Publication Date:
February 09, 2023
Filing Date:
August 01, 2022
Export Citation:
Assignee:
MEDICAL ARK INC (JP)
International Classes:
C12Q1/6886; C12N15/09; C12Q1/6813
Domestic Patent References:
| WO2020179895A1 | 2020-09-10 | |||
| WO2020032228A1 | 2020-02-13 | |||
| WO2019208671A1 | 2019-10-31 | |||
| WO2015194615A1 | 2015-12-23 |
Foreign References:
| JP2014082953A | 2014-05-12 | |||
| JP2021158996A | 2021-10-11 |
Other References:
IOANNIDIS JASON, DONADEU F. XAVIER: "Circulating microRNA Profiles during the Bovine Oestrous Cycle", PLOS ONE, vol. 11, no. 6, 23 May 2017 (2017-05-23), pages e0158160, XP093032679, DOI: 10.1371/journal.pone.0158160
CRAIG KARLEE K. L., WOOD GEOFFREY A., KELLER STEFAN M., MUTSAERS ANTHONY J., WOOD R. DARREN: "MicroRNA profiling in canine multicentric lymphoma", PLOS ONE, vol. 14, no. 12, 11 December 2019 (2019-12-11), pages e0226357, XP093032685, DOI: 10.1371/journal.pone.0226357
KENT MICHAEL S., ZWINGENBERGER ALLISON, WESTROPP JODI L., BARRETT LAURA E., DURBIN-JOHNSON BLYTHE P., GHOSH PARAMITA, VINALL RUTH : "MicroRNA profiling of dogs with transitional cell carcinoma of the bladder using blood and urine samples", BMC VETERINARY RESEARCH, vol. 13, no. 1, 1 December 2017 (2017-12-01), XP093032687, DOI: 10.1186/s12917-017-1259-1
FISH ERIC J., MARTINEZ‐ROMERO ESTHER GISELA, DEINNOCENTES PATRICIA, KOEHLER JEY W., PRASAD NRIPESH, SMITH ANNETTE N., BIRD RICHARD: "Circulating microRNA as biomarkers of canine mammary carcinoma in dogs", JOURNAL OF VETERINARY INTERNAL MEDICINE, WILEY-BLACKWELL PUBLISHING, INC., US, vol. 34, no. 3, 1 May 2020 (2020-05-01), US , pages 1282 - 1290, XP093032689, ISSN: 0891-6640, DOI: 10.1111/jvim.15764
BØRRESEN B., NIELSEN L. N., JESSEN L. R., KRISTENSEN A. T., FREDHOLM M., CIRERA S.: "Circulating let‐7g is down‐regulated in Bernese Mountain dogs with disseminated histiocytic sarcoma and carcinomas – a prospective study", VETERINARY AND COMPARATIVE ONCOLOGY, vol. 15, no. 2, 1 June 2017 (2017-06-01), pages 525 - 533, XP093032690, ISSN: 1476-5810, DOI: 10.1111/vco.12196
HEISHIMA KAZUKI, MORI TAKASHI, ICHIKAWA YUKIE, SAKAI HIROKI, KURANAGA YUKI, NAKAGAWA TAKAYUKI, TANAKA YUIKO, OKAMURA YASUHIKO, MAS: "MicroRNA-214 and MicroRNA-126 Are Potential Biomarkers for Malignant Endothelial Proliferative Diseases", INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, vol. 16, no. 10, pages 25377 - 25391, XP093032692, DOI: 10.3390/ijms161025377
土屋玲子ほか. マイクロＲＮＡを用いたイヌ悪性腫瘍における早期診断法の確立. 第４１回日本分子腫瘍マーカー研究会プログラム・講演抄録集. 29 September 2021, pp. 78-79, (TSUCHIYA, Reiko et al. Establishment of an early diagnosis method for canine malignant tumors using circulating microRNA), non-official translation (Program and Abstracts of the 41st Meeting of the Japan Society for Molecular Tumor Marker Research.) entire text
CRAIG KARLEE K. L., WOOD GEOFFREY A., KELLER STEFAN M., MUTSAERS ANTHONY J., WOOD R. DARREN: "MicroRNA profiling in canine multicentric lymphoma", PLOS ONE, vol. 14, no. 12, 11 December 2019 (2019-12-11), pages e0226357, XP093032685, DOI: 10.1371/journal.pone.0226357
KENT MICHAEL S., ZWINGENBERGER ALLISON, WESTROPP JODI L., BARRETT LAURA E., DURBIN-JOHNSON BLYTHE P., GHOSH PARAMITA, VINALL RUTH : "MicroRNA profiling of dogs with transitional cell carcinoma of the bladder using blood and urine samples", BMC VETERINARY RESEARCH, vol. 13, no. 1, 1 December 2017 (2017-12-01), XP093032687, DOI: 10.1186/s12917-017-1259-1
FISH ERIC J., MARTINEZ‐ROMERO ESTHER GISELA, DEINNOCENTES PATRICIA, KOEHLER JEY W., PRASAD NRIPESH, SMITH ANNETTE N., BIRD RICHARD: "Circulating microRNA as biomarkers of canine mammary carcinoma in dogs", JOURNAL OF VETERINARY INTERNAL MEDICINE, WILEY-BLACKWELL PUBLISHING, INC., US, vol. 34, no. 3, 1 May 2020 (2020-05-01), US , pages 1282 - 1290, XP093032689, ISSN: 0891-6640, DOI: 10.1111/jvim.15764
BØRRESEN B., NIELSEN L. N., JESSEN L. R., KRISTENSEN A. T., FREDHOLM M., CIRERA S.: "Circulating let‐7g is down‐regulated in Bernese Mountain dogs with disseminated histiocytic sarcoma and carcinomas – a prospective study", VETERINARY AND COMPARATIVE ONCOLOGY, vol. 15, no. 2, 1 June 2017 (2017-06-01), pages 525 - 533, XP093032690, ISSN: 1476-5810, DOI: 10.1111/vco.12196
HEISHIMA KAZUKI, MORI TAKASHI, ICHIKAWA YUKIE, SAKAI HIROKI, KURANAGA YUKI, NAKAGAWA TAKAYUKI, TANAKA YUIKO, OKAMURA YASUHIKO, MAS: "MicroRNA-214 and MicroRNA-126 Are Potential Biomarkers for Malignant Endothelial Proliferative Diseases", INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, vol. 16, no. 10, pages 25377 - 25391, XP093032692, DOI: 10.3390/ijms161025377
土屋玲子ほか. マイクロＲＮＡを用いたイヌ悪性腫瘍における早期診断法の確立. 第４１回日本分子腫瘍マーカー研究会プログラム・講演抄録集. 29 September 2021, pp. 78-79, (TSUCHIYA, Reiko et al. Establishment of an early diagnosis method for canine malignant tumors using circulating microRNA), non-official translation (Program and Abstracts of the 41st Meeting of the Japan Society for Molecular Tumor Marker Research.) entire text
Attorney, Agent or Firm:
EINSEL Felix-Reinhard et al. (JP)
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