Title:
METHOD OF DIAGNOSING ALZHEIMER’S DISEASE USING SERUM GLYCOPROTEIN AS BIOMARKER
Document Type and Number:
WIPO Patent Application WO/2006/121099
Kind Code:
A1
Abstract:
It is intended to provide a diagnostic agent and a diagnostic method for sporadic Alzheimer’s disease by detecting a metabolic change of a glycoprotein having &agr 2,6-sialate residue in the blood. It is also intended to provide a diagnostic agent for Alzheimer’s disease which comprises lectin for detecting an &agr 2,6-sialate-containing glycoprotein.
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Inventors:
KITAZUME SHINOBU (JP)
OKA RITSUKO (JP)
HASHIMOTO YASUHIRO (JP)
SATO YUJI (JP)
ENDO TAMAO (JP)
HIGUCHI MASATO (JP)
ARAI HIROYUKI (JP)
SAIDO TAKAOMI (JP)
OKA RITSUKO (JP)
HASHIMOTO YASUHIRO (JP)
SATO YUJI (JP)
ENDO TAMAO (JP)
HIGUCHI MASATO (JP)
ARAI HIROYUKI (JP)
SAIDO TAKAOMI (JP)
Application Number:
PCT/JP2006/309450
Publication Date:
November 16, 2006
Filing Date:
May 11, 2006
Export Citation:
Assignee:
RIKEN (JP)
KITAZUME SHINOBU (JP)
OKA RITSUKO (JP)
HASHIMOTO YASUHIRO (JP)
SATO YUJI (JP)
ENDO TAMAO (JP)
HIGUCHI MASATO (JP)
ARAI HIROYUKI (JP)
SAIDO TAKAOMI (JP)
KITAZUME SHINOBU (JP)
OKA RITSUKO (JP)
HASHIMOTO YASUHIRO (JP)
SATO YUJI (JP)
ENDO TAMAO (JP)
HIGUCHI MASATO (JP)
ARAI HIROYUKI (JP)
SAIDO TAKAOMI (JP)
International Classes:
G01N33/53
Other References:
JOHNSON ET AL.: "Cerebrospinal fluid protein variations in common to Alzheimer's disease and schizophrenia", APPLIED AND THEORETICAL ELECTROPHORESIS, vol. 3, 1992, pages 47 - 53, XP009014286
SPAGNUOLO ET AL.: "The Binding of Haptoglobin to Apolipoprotein A1: Influence of Hemoglobin and Concanavalin A", BIOL. CHEM., vol. 384, 2003, pages 1593 - 1596, XP009062164
KITAZUME ET AL.: "Alzheimer's beta-secretase cleaves a glycosyltranferase as a physiological substrate", GLYCOCONJUGATE JOURNAL, vol. 20, 2004, pages 59 - 62, XP003003351
KITAZUME ET AL.: "In Vivo Cleavage of alpha2,6-Sialyltransferase by Alzheimer beta-secretase", THE JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 280, no. 9, March 2005 (2005-03-01), pages 8589 - 8595, XP003003352
JOHNSON ET AL., APPLIED AND THEORETICAL ELECTROPHORESIS, vol. 3, no. 2, 1992, pages 47 - 53
YASUKAWA ET AL., GLYCOBIOLOGY, vol. 15, no. 9, 2005, pages 827 - 837
See also references of EP 1901066A4
SPAGNUOLO ET AL.: "The Binding of Haptoglobin to Apolipoprotein A1: Influence of Hemoglobin and Concanavalin A", BIOL. CHEM., vol. 384, 2003, pages 1593 - 1596, XP009062164
KITAZUME ET AL.: "Alzheimer's beta-secretase cleaves a glycosyltranferase as a physiological substrate", GLYCOCONJUGATE JOURNAL, vol. 20, 2004, pages 59 - 62, XP003003351
KITAZUME ET AL.: "In Vivo Cleavage of alpha2,6-Sialyltransferase by Alzheimer beta-secretase", THE JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 280, no. 9, March 2005 (2005-03-01), pages 8589 - 8595, XP003003352
JOHNSON ET AL., APPLIED AND THEORETICAL ELECTROPHORESIS, vol. 3, no. 2, 1992, pages 47 - 53
YASUKAWA ET AL., GLYCOBIOLOGY, vol. 15, no. 9, 2005, pages 827 - 837
See also references of EP 1901066A4
Attorney, Agent or Firm:
SIKs & Co. (Kyobashi-Nisshoku Bldg. 8-7, Kyobashi 1-chom, Chuo-ku Tokyo 31, JP)
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