Title:
METHOD FOR DIFFERENTIATING OR COMPARING DRUG ACTIVITY MODULE
Document Type and Number:
WIPO Patent Application WO/2017/211059
Kind Code:
A1
Abstract:
Provided is a method for differentiating or comparing a drug activity module. The method comprising the following steps:(1) performing module categorization of two biological networks to obtain a modular set; (2) calculating one or more topological characteristics of two modular sets to obtain a single or combined topological indicator, and using the topological indicator to calculate a topological parameter change of a module corresponding to the two modular sets; and (3) comparing the topological parameter change of the module and a significance threshold; if the two biological networks are respectively a pre-drug intervention biological network and a post-drug intervention biological network, and if the topological parameter change is greater or equal to the significance threshold, then categorizing the module as a drug activity module; if the two biological networks are respectively a post-intervention biological network for a first drug and a post-intervention biological network for a second drug, and if the topological parameter change is greater or equal to the significance threshold, then categorizing the module as an activity difference module between a first drug and a second drug.
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Inventors:
WANG ZHONG (CN)
LI BING (CN)
LI BING (CN)
Application Number:
PCT/CN2016/109895
Publication Date:
December 14, 2017
Filing Date:
December 14, 2016
Export Citation:
Assignee:
WANG ZHONG (CN)
LI BING (CN)
LI BING (CN)
International Classes:
G16B5/00
Domestic Patent References:
| WO2015054266A1 | 2015-04-16 |
Foreign References:
| CN103778349A | 2014-05-07 | |||
| CN103782301A | 2014-05-07 | |||
| CN103514381A | 2014-01-15 |
Other References:
See also references of EP 3467689A4
Attorney, Agent or Firm:
LEADING INTELLECTUAL PROPERTY FIRM (CN)
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