A METHOD OF DIFFERENTIATING AN INDUCED PLURIPOTENT STEM CELL INTO A RETINAL PIGMENT EPITHELIAL CELL, A RETINAL PIGMENT EPITHELIAL CELL AND METHODS OF USING THE RETINAL PIGMENT EPITHELIAL CELL

WIPO Patent Application WO/2023/146477

A3

The present invention relates to a method of differentiating an induced pluripotent stem cell into a retinal pigment epithelial cell. Additionally, the present invention relates to a retinal pigment epithelial cell culture obtainable by the differentiation method and a retinal pigment epithelial cell culture obtained by the differentiation method. In addition, the present invention concerns a retinal pigment epithelium consisting of or comprising a retinal pigment epithelial cell culture obtainable or obtained by the differentiation method. The present invention also relates to a pharmaceutical composition comprising a retinal pigment epithelial cell culture obtained by the differentiation method. The present invention concerns a method of treating a retinal degenerative disease in a subject, comprising administering to a subject a retinal pigment epithelial cell differentiated from the induced pluripotent stem cell by the method. Finally, the present invention also refers to an in vivo method of detecting the survival rate of a retinal pigment epithelial cell differentiated from an induced pluripotent stem cell by the defined method in a subject and an in vitro method of determining the immunogenicity of said retinal pigment epithelial cell differentiated from an induced pluripotent stem cell by the defined method in said subject, to whom said differentiated RPE cell has been pre-delivered.

SU XINYI (SG)
KAKKAD REGHA (SG)
BHARGAVA MAYURI (SG)
YANG BINXIA (SG)
HUNZIKER WALTER (SG)
LIU ZENGPING (SG)
WANG HAOFEI (SG)
PARIKH BHAV HARSHAD (SG)
CHEN QINGFENG (SG)
LAI FRITZ (SG)
LIM KAH LEONG (SG)
PHAN TOAN THANG (SG)
CHAI CHOU

PCT/SG2023/050051

October 19, 2023

January 27, 2023

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AGENCY SCIENCE TECH & RES (SG)
CELLRESEARCH CORP PTE LTD (SG)
SINGAPORE HEALTH SERV PTE LTD (SG)

C12N5/071; A61K35/12; A61P27/00

WO2014121077A2

2014-08-07

CN108531443A

2018-09-14

LEAH P. FOLTZ, DENNIS O. CLEGG: "Rapid, Directed Differentiation of Retinal Pigment Epithelial Cells from Human Embryonic or Induced Pluripotent Stem Cells", JOURNAL OF VISUALIZED EXPERIMENTS, vol. 379156274, no. 128, 1 January 2017 (2017-01-01), pages 56274, XP055771275, DOI: 10.3791/56274
CHOU CHAI, RU ONG, CHENG ZHANG, BING CHAI, LI QIU, MOOGAAMBIKAI THANGAVELOO, DEJIE YU, TUCK SOONG, BENG ANG, SOO TANG, LI ZENG, EN: "Umbilical Cord Lining-derived Induced Pluripotent Stem Cells as a Novel Source for Cell Replacement Therapy of Parkinson's Disease", MOVEMENT DISORDERS, vol. 31, no. Suppl. 1, 10 March 2016 (2016-03-10), US , pages S64, XP009542901, ISSN: 0885-3185
ANONYMOUS: "Cord Lining", WIKIPEDIA, 29 August 2023 (2023-08-29), pages 1 - 3, XP093102925, Retrieved from the Internet [retrieved on 20231117]
"Recent Advances in Ophthalmology", vol. 15, 30 October 2021, ISBN: 978-93-90595-85-3, article LINGAM GOPAL; SU XINYI; BHARGAVA MAYURI; LIU ZENGPING; SWATHI LINGAM: "Newer Approaches to Management of Retinal Degenerative Disorders: Gene Therapy and Cell Replacement Therapy", pages: 204 - 228, XP009550383

MCLAUGHLIN, Michael, Gerard et al. (SG)

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