METHOD FOR DIFFERENTIATING MESENCHYMAL STEM CELLS FROM PLURIPOTENT STEM CELLS

Title:

METHOD FOR DIFFERENTIATING MESENCHYMAL STEM CELLS FROM PLURIPOTENT STEM CELLS

Document Type and Number:

WIPO Patent Application WO/2021/225420

Kind Code:

A1

Abstract:

The present invention relates to a method for producing mesenchymal stem cells from pluripotent stem cells and to mesenchymal stem cells produced by the method. The present invention enables mesenchymal stem cells having an excellent proliferation rate while having superior intrinsic biological activity to be obtained in high yield by sequentially performing three-dimensional suspension culture by using pluripotent stem cells, particularly induced pluripotent stem cells (iPSCs), as starting cells, and adherent culture of cell aggregates formed through same. In addition, mesenchymal stem cells produced by the method of the present invention demonstrate high efficiency of differentiation into bone and cartilage and have excellent anti-inflammatory activity, and thus can be usefully used as compositions for treatment of bone diseases, cartilage diseases, or inflammation and autoimmune diseases.

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Inventors:

CHO SSANG-GOO (KR)
ABDAL DAYEM AHMED (KR)
LEE SOO BIN (KR)

Application Number:

PCT/KR2021/005767

Publication Date:

November 11, 2021

Filing Date:

May 07, 2021

Export Citation:

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Assignee:

UNIV KONKUK IND COOP CORP (KR)

International Classes:

C12N5/0775; A61K35/28; A61P19/00; A61P29/00

Domestic Patent References:

WO2013130075A1

2013-09-06

Foreign References:

US20110027880A1	2011-02-03
CN105734017A	2016-07-06
CN101892195A	2010-11-24

Other References:

ZHANG SHICHANG; LIU PING; CHEN LI; WANG YINGJIE; WANG ZHENGGUO; ZHANG BO: "The effects of spheroid formation of adipose-derived stem cells in a microgravity bioreactor on stemness properties and therapeutic potential", BIOMATERIALS, vol. 41, 1 December 2014 (2014-12-01), pages 15 - 25, XP029116876, ISSN: 0142-9612, DOI: 10.1016/j.biomaterials.2014.11.019

Attorney, Agent or Firm:

CHUNG HYUN PATENT & LAW FIRM (KR)

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