Title:
METHOD FOR DIFFERENTIATING NERVE CELLS AND HAIR CELLS FROM PLACENTAL CHORION OR WARTHON'S JELLY-DERIVED MESENCHYMAL STEM CELLS
Document Type and Number:
WIPO Patent Application WO/2015/080376
Kind Code:
A1
Abstract:
The present invention relates to a method for differentiating stem cells isolated from human placental chorion or Warthon's jelly and, more specifically, to a method for differentiating chorion or Warthon's jelly-derived stem cells into neural cell precursors, hair cells and nerve cells, the method comprising culturing stem cells, isolated from human placental chorion or Warthon's jelly, in a culture medium containing a nerve growth factor. In addition, the present invention relates to a composition for preventing or treating hearing loss, comprising the differentiated neural cell precursors, hair cells and neural cells as active ingredients.
Inventors:
PARK KYOUNG HO (KR)
KIL KI CHEOL (KR)
CHOI MI YOUNG (KR)
KIL KI CHEOL (KR)
CHOI MI YOUNG (KR)
Application Number:
PCT/KR2014/009485
Publication Date:
June 04, 2015
Filing Date:
October 08, 2014
Export Citation:
Assignee:
CATHOLIC UNIV KOREA INDUSTRY ACADEMIC COOPERATION FOUNDATION (KR)
International Classes:
C12N5/079; A61K35/30; C12N5/02; C12N5/073
Foreign References:
| KR20130039467A | 2013-04-22 | |||
| KR20130028294A | 2013-03-19 | |||
| KR100449141B1 | 2004-09-21 |
Other References:
PORTMANN-LANZ, C. BETTINA ET AL.: "Turning placenta into brain: placental mesenchymal stem cells differentiate into neurons and oligodendmeytes", AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY, vol. 202, no. 3, 2010, pages 294.E1 - 294.E11
MITCHELL, KATHY E. ET AL.: "Matrix cells from Wharton's jelly form neurons and glia", STEM CELLS, vol. 21, no. 1, 2003, pages 50 - 60
CHOI, YONG-SEOK ET AL.: "Functional analysis of differentiated neurons and hair cells from mesenchymal stem cells of human placental tissue", 19TH OTORHINOLARYNGOLOGY CONFERENCE, 11 October 2013 (2013-10-11)
MITCHELL, KATHY E. ET AL.: "Matrix cells from Wharton's jelly form neurons and glia", STEM CELLS, vol. 21, no. 1, 2003, pages 50 - 60
CHOI, YONG-SEOK ET AL.: "Functional analysis of differentiated neurons and hair cells from mesenchymal stem cells of human placental tissue", 19TH OTORHINOLARYNGOLOGY CONFERENCE, 11 October 2013 (2013-10-11)
Attorney, Agent or Firm:
BAE, KIM & LEE IP GROUP (KR)
특허법인 태평양 (KR)
특허법인 태평양 (KR)
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