Title:
METHOD OF DISCOVERING BIOACTIVE SUBSTANCE USING PLANTS BASED ON EFFICACY
Document Type and Number:
WIPO Patent Application WO/2015/194843
Kind Code:
A1
Abstract:
The present invention relates to a method of discovering a bioactive substance using plants based on efficacy, and is intended to discover a lead material for a novel drug by repetitively performing screening experiments based on a phenotype of a developmental biological marker of plants. To achieve this purpose, the present invention provides a method of discovering a bioactive material using plants based on efficacy, which is characterized in that candidate materials for novel drug development are screened by using, as a marker, a specific phenotype expressed in a plant when the plant is treated with a certain material.
Inventors:
CHOE SUNGHWA (KR)
PUNA MAYA MAHARJAN (KR)
PARK SLKI (KR)
CHA RICHARD (KR)
PUNA MAYA MAHARJAN (KR)
PARK SLKI (KR)
CHA RICHARD (KR)
Application Number:
PCT/KR2015/006118
Publication Date:
December 23, 2015
Filing Date:
June 17, 2015
Export Citation:
Assignee:
UNIV SEOUL NAT R & DB FOUND (KR)
International Classes:
C12Q1/02; A01H5/00
Foreign References:
| KR101346586B1 | 2014-01-15 |
Other References:
MIN, YONG GI: "Collaboration between Chemistry - Development and Prospect of Chemical genomics", SCIENCE TOUCH ON FRIDAY, 22 May 2009 (2009-05-22)
YOO ET AL.: "Arabidopsis mesophyll protoplasts: a versatile cell system for transient gene expression analysis", NATURE PROTOCOLS, vol. 2, no. 7, 2007, pages 1565 - 1572, XP002621444, DOI: doi:10.1038/NPROT.2007.199
CHOI, MIN - KYUNG ET AL.: "The Application of High Performance Thin Layer Chromatography for Herbal Formula Standardization", J. KOREAN ORIENTAL MED, vol. 32, no. 4, 2011, pages 68 - 74
BALUNAS ET AL.: "Drug discovery from medicinal plants", LIFE SCIENCES, vol. 78, no. 5, 2005, pages 431 - 441, XP005171772, DOI: doi:10.1016/j.lfs.2005.09.012
SHIMADA ET AL.: "Formation and dissociation of the BSS1 protein complex regulates plant development via brassinosteroid signaling", THE PLANT CELL, vol. 27, no. 2, January 2015 (2015-01-01), pages 375 - 390, XP055245307, ISSN: 1040-4651
YOO ET AL.: "Arabidopsis mesophyll protoplasts: a versatile cell system for transient gene expression analysis", NATURE PROTOCOLS, vol. 2, no. 7, 2007, pages 1565 - 1572, XP002621444, DOI: doi:10.1038/NPROT.2007.199
CHOI, MIN - KYUNG ET AL.: "The Application of High Performance Thin Layer Chromatography for Herbal Formula Standardization", J. KOREAN ORIENTAL MED, vol. 32, no. 4, 2011, pages 68 - 74
BALUNAS ET AL.: "Drug discovery from medicinal plants", LIFE SCIENCES, vol. 78, no. 5, 2005, pages 431 - 441, XP005171772, DOI: doi:10.1016/j.lfs.2005.09.012
SHIMADA ET AL.: "Formation and dissociation of the BSS1 protein complex regulates plant development via brassinosteroid signaling", THE PLANT CELL, vol. 27, no. 2, January 2015 (2015-01-01), pages 375 - 390, XP055245307, ISSN: 1040-4651
Attorney, Agent or Firm:
KIM, KYUNG HEE (KR)
김경희 (KR)
김경희 (KR)
Download PDF: