Title:
METHOD FOR DISCOVERING BIOMARKER FOR DIAGNOSING FATTY LIVER DISEASE
Document Type and Number:
WIPO Patent Application WO/2024/010134
Kind Code:
A1
Abstract:
The present invention relates to a method for discovering a biomarker for diagnosing fatty liver disease and, more specifically, to a method for discovering a biomarker for diagnosing fatty liver disease, comprising: a first step of selecting a correlated miRNA and pathway combination (hereinafter, referred to as miRNA-pathway); a second step of selecting a miRNA-pathway target specific to fatty liver disease through integrated analysis of the miRNA-pathway selected in the first step and gene expression data (RNA-seq) of fatty liver disease; and a third step of deriving a miRNA-pathway regulatory network that directly regulates fatty liver disease genes from the target selected in the second step. A miRNA regulatory network that is statistically significant in liver disease can be constructed through integrated analysis of database information, and from this, a miRNA target specific to fatty liver disease can be selected and used as a diagnostic marker or therapeutic composition for fatty liver disease.
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Inventors:
NAM DOUGU (KR)
Application Number:
PCT/KR2022/012573
Publication Date:
January 11, 2024
Filing Date:
August 23, 2022
Export Citation:
Assignee:
UNIST ACADEMY INDUSTRY RES CORPORATION (KR)
International Classes:
C12Q1/6883
Foreign References:
| KR20120044100A | 2012-05-07 | |||
| KR20200065385A | 2020-06-09 |
Other References:
CHANG SHIH-HSIN, SU YI-CHING, CHANG MIEN, CHEN JUN-AN: "MicroRNAs mediate precise control of spinal interneuron populations to exert delicate sensory-to-motor outputs", ELIFE, ELIFE SCIENCES PUBLICATIONS LTD., GB, vol. 10, 31 March 2021 (2021-03-31), GB , XP093124832, ISSN: 2050-084X, DOI: 10.7554/eLife.63768
LIU JINGQI, LIN BOGENG, CHEN ZHIQING, DENG MANXIANG, WANG YE, WANG JISU, CHEN LULING, ZHANG ZHENYU, XIAO XUELING, CHEN CHUNLIN, SO: "Identification of key pathways and genes in nonalcoholic fatty liver disease using bioinformatics analysis", ARCHIVES OF MEDICAL SCIENCE, TERMEDIA PUBLISHING HOUSE LTD., vol. 16, no. 2, 1 January 2020 (2020-01-01), pages 374 - 385, XP093126358, ISSN: 1734-1922, DOI: 10.5114/aoms.2020.93343
VULF MARIA, SHUNKINA DARIA, KOMAR ALEKSANDRA, BOGRAYA MARIA, ZATOLOKIN PAVEL, KIRIENKOVA ELENA, GAZATOVA NATALIA, KOZLOV IVAN, LIT: "Analysis of miRNAs Profiles in Serum of Patients With Steatosis and Steatohepatitis", FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY, FRONTIERS MEDIA, CH, vol. 9, 9 September 2021 (2021-09-09), CH , pages 736677, XP093126359, ISSN: 2296-634X, DOI: 10.3389/fcell.2021.736677
LIU JINGQI, LIN BOGENG, CHEN ZHIQING, DENG MANXIANG, WANG YE, WANG JISU, CHEN LULING, ZHANG ZHENYU, XIAO XUELING, CHEN CHUNLIN, SO: "Identification of key pathways and genes in nonalcoholic fatty liver disease using bioinformatics analysis", ARCHIVES OF MEDICAL SCIENCE, TERMEDIA PUBLISHING HOUSE LTD., vol. 16, no. 2, 1 January 2020 (2020-01-01), pages 374 - 385, XP093126358, ISSN: 1734-1922, DOI: 10.5114/aoms.2020.93343
VULF MARIA, SHUNKINA DARIA, KOMAR ALEKSANDRA, BOGRAYA MARIA, ZATOLOKIN PAVEL, KIRIENKOVA ELENA, GAZATOVA NATALIA, KOZLOV IVAN, LIT: "Analysis of miRNAs Profiles in Serum of Patients With Steatosis and Steatohepatitis", FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY, FRONTIERS MEDIA, CH, vol. 9, 9 September 2021 (2021-09-09), CH , pages 736677, XP093126359, ISSN: 2296-634X, DOI: 10.3389/fcell.2021.736677
Attorney, Agent or Firm:
KIM, Jong Seok (KR)
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