Title:
METHOD FOR DISCOVERING CELL SURFACE ANTIGENS FOR NOVEL ANTIBODIES
Document Type and Number:
WIPO Patent Application WO/2024/010416
Kind Code:
A1
Abstract:
The present invention relates to a method for discovering cell surface antigens for novel antibodies. A screening method according to an aspect can accurately screen for cell surface antigens that bind to novel antibodies. Moreover, the method is effective in efficiently screening for cell surface antigens corresponding to novel antibodies by using cells that bind well with the antibodies.
Inventors:
CHANG SU HWAN (KR)
KIM YONG SUB (KR)
CHOI EUN A (KR)
KIM YONG SUB (KR)
CHOI EUN A (KR)
Application Number:
PCT/KR2023/009648
Publication Date:
January 11, 2024
Filing Date:
July 07, 2023
Export Citation:
Assignee:
ASAN FOUND (KR)
UNIV ULSAN FOUND IND COOP (KR)
UNIV ULSAN FOUND IND COOP (KR)
International Classes:
G01N33/574; C12N9/22; C12Q1/6869
Domestic Patent References:
| WO2020219913A1 | 2020-10-29 |
Foreign References:
| US20210317443A1 | 2021-10-14 |
Other References:
WANG ERIC, ZHOU HUA, NADORP BETTINA, CAYANAN GERALDINE, CHEN XUFENG, YEATON ANNA H., NOMIKOU SOFIA, WITKOWSKI MATTHEW T., NARANG S: "Surface antigen-guided CRISPR screens identify regulators of myeloid leukemia differentiation", CELL STEM CELL, ELSEVIER, CELL PRESS, AMSTERDAM, NL, vol. 28, no. 4, 1 April 2021 (2021-04-01), AMSTERDAM, NL , pages 718 - 731.e6, XP093125678, ISSN: 1934-5909, DOI: 10.1016/j.stem.2020.12.005
KLEIN KLARA, HÖLZEMER ANGELIQUE, WANG TIM, KIM TAE-EUN, DUGAN HALEY L., JOST STEPHANIE, ALTFELD MARCUS, GARCIA-BELTRAN WILFREDO F.: "A Genome-Wide CRISPR/Cas9-Based Screen Identifies Heparan Sulfate Proteoglycans as Ligands of Killer-Cell Immunoglobulin-Like Receptors", FRONTIERS IN IMMUNOLOGY, FRONTIERS MEDIA, LAUSANNE, CH, vol. 12, 30 November 2021 (2021-11-30), Lausanne, CH , pages .798235, XP093125681, ISSN: 1664-3224, DOI: 10.3389/fimmu.2021.798235
HE CHENGLONG, HAN SIQI, CHANG YUE, WU MEIJUAN, ZHAO YULU, CHEN CHENG, CHU XIAOYUAN: "CRISPR screen in cancer: status quo and future perspectives", AMERICAN JOURNAL OF CANCER RESEARCH, E-CENTURY PUBLISHING CORPORATION, US, vol. 11, no. 4, 1 January 2021 (2021-01-01), US , pages 1031 - 1050, XP093125683, ISSN: 2156-6976
KLEIN KLARA, HÖLZEMER ANGELIQUE, WANG TIM, KIM TAE-EUN, DUGAN HALEY L., JOST STEPHANIE, ALTFELD MARCUS, GARCIA-BELTRAN WILFREDO F.: "A Genome-Wide CRISPR/Cas9-Based Screen Identifies Heparan Sulfate Proteoglycans as Ligands of Killer-Cell Immunoglobulin-Like Receptors", FRONTIERS IN IMMUNOLOGY, FRONTIERS MEDIA, LAUSANNE, CH, vol. 12, 30 November 2021 (2021-11-30), Lausanne, CH , pages .798235, XP093125681, ISSN: 1664-3224, DOI: 10.3389/fimmu.2021.798235
HE CHENGLONG, HAN SIQI, CHANG YUE, WU MEIJUAN, ZHAO YULU, CHEN CHENG, CHU XIAOYUAN: "CRISPR screen in cancer: status quo and future perspectives", AMERICAN JOURNAL OF CANCER RESEARCH, E-CENTURY PUBLISHING CORPORATION, US, vol. 11, no. 4, 1 January 2021 (2021-01-01), US , pages 1031 - 1050, XP093125683, ISSN: 2156-6976
Attorney, Agent or Firm:
THEWAVE IP LAW FIRM (KR)
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