Title:
METHOD FOR DISCOVERY OF MICRORNA BIOMARKER FOR CANCER DIAGNOSIS, AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2017/099414
Kind Code:
A1
Abstract:
The present invention relates to a method for discovery of a novel miRNA biomarker for cancer diagnosis, a biomarker for diagnosis of bile duct cancer or pancreatic cancer which has been discovered through the method for discovery of a biomarker, a method for diagnosing cancer, comprising a step in which cancer is diagnosed when f(x) > 0 by substitution of the expression level of the miRNA biomarker, which is detected by the method for discovery of an miRNA biomarker for cancer diagnosis, in a sample into a novel SVM classifier function, a kit for diagnosing bile duct cancer or pancreatic cancer comprising the biomarker for diagnosing bile duct cancer or pancreatic cancer, and a computing device for performing a process of diagnosing cancer when f(x) > 0 as a result of a calculation by substitution of the expression level of an miRNA biomarker, which is detected by the method for discovery of an miRNA biomarker for cancer diagnosis, into the novel SVM classifier function.
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Inventors:
LEE JAEHOON (KR)
LEE JUNGSU (KR)
LEE CHANGHEE (KR)
HEO JEEYEON (KR)
CHOI HYUNGSEOK (KR)
SONG SIYOUNG (KR)
JUNG DAWOON (KR)
LEE JUNGSU (KR)
LEE CHANGHEE (KR)
HEO JEEYEON (KR)
CHOI HYUNGSEOK (KR)
SONG SIYOUNG (KR)
JUNG DAWOON (KR)
Application Number:
PCT/KR2016/013975
Publication Date:
June 15, 2017
Filing Date:
November 30, 2016
Export Citation:
Assignee:
LG ELECTRONICS INC (KR)
INDUSTRY-ACADEMIC COOPERATION FOUNDATION YONSEI UNIV (KR)
INDUSTRY-ACADEMIC COOPERATION FOUNDATION YONSEI UNIV (KR)
International Classes:
C12Q1/68; G16B20/20; G16B40/20
Domestic Patent References:
| WO2015182781A1 | 2015-12-03 | |||
| WO2015190542A1 | 2015-12-17 |
Foreign References:
| US20150011414A1 | 2015-01-08 | |||
| US20090099034A1 | 2009-04-16 |
Other References:
KOJIMA: "MicroRNA markers for the diagnosis of pancreatic and biliary- tract cancers", PLOS ONE, vol. 10, no. 2, 23 February 2015 (2015-02-23), pages 1 - 22, XP055382030, DOI: doi:10.1371/journal.pone.0118220
HUBENTHAL: "Sparse modeling reveals miRNA signatures for diagnostics of inflammatory bowel disease", PLOS ONE, vol. 10, no. 10, 14 October 2015 (2015-10-14), pages 1 - 20, XP055598904, ISSN: 1932-6203, DOI: 10.1371/journal.pone.0140155
HUBENTHAL: "Sparse modeling reveals miRNA signatures for diagnostics of inflammatory bowel disease", PLOS ONE, vol. 10, no. 10, 14 October 2015 (2015-10-14), pages 1 - 20, XP055598904, ISSN: 1932-6203, DOI: 10.1371/journal.pone.0140155
Attorney, Agent or Firm:
PARK, Jang-Won (KR)
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