Title:
METHOD FOR EARLY DIAGNOSING ALZHEIMER'S DISEASE, DISTINGUISHING STAGES OF ALZHEIMER'S DISEASE, AND DETERMINING ACCUMULATION OF AMYLOID BETA IN BRAIN, USING PHOSPHORYLATED PEPTIDE DERIVED FROM ALZHEIMER DEMENTIA-RELATED PROTEIN
Document Type and Number:
WIPO Patent Application WO/2024/005592
Kind Code:
A1
Abstract:
The present invention relates to a method for the early diagnosis of Alzheimer's disease using phosphorylated peptides and, specifically, to a method for early diagnosing Alzheimer's disease or for distinguishing stages of Alzheimer's disease and a method for determining the accumulation of amyloid beta in the brain, each method including measuring phosphorylation levels of Alzheimer's dementia-related proteins in biological samples. The method for the quantitation of phosphorylated peptides derived from Alzheimer's dementia-related proteins according to the present invention allows for effective early diagnosis or stage distinguishment of Alzheimer's disease and makes it possible to determine the accumulation of amyloid beta in the brain.
Inventors:
PARK ZEE-YONG (KR)
JANG SE HWAN (KR)
HWANG DAEHEE (KR)
LEE KUNHO (KR)
JANG SE HWAN (KR)
HWANG DAEHEE (KR)
LEE KUNHO (KR)
Application Number:
PCT/KR2023/009232
Publication Date:
January 04, 2024
Filing Date:
June 30, 2023
Export Citation:
Assignee:
GWANGJU INST SCIENCE & TECH (KR)
SEOUL NAT UNIV R&DB FOUNDATION (KR)
UNIV CHOSUN IACF (KR)
SEOUL NAT UNIV R&DB FOUNDATION (KR)
UNIV CHOSUN IACF (KR)
International Classes:
G01N33/68; G01N30/02
Foreign References:
| JP2018519505A | 2018-07-19 | |||
| KR20210004996A | 2021-01-13 | |||
| US20030032070A1 | 2003-02-13 |
Other References:
WANG FANGJUN, BLANCHARD ALEXANDRE P., ELISMA FRED, GRANGER MATTHEW, XU HONGBIN, BENNETT STEFFANY A. L., FIGEYS DANIEL, ZOU HANFA: "Phosphoproteome analysis of an early onset mouse model (TgCRND8) of alzheimer’s disease reveals temporal changes in neuronal and glia signaling pathways", PROTEOMICS, WILEY-VCH VERLAG , WEINHEIM, DE, vol. 13, no. 8, 1 April 2013 (2013-04-01), DE , pages 1292 - 1305, XP093121985, ISSN: 1615-9853, DOI: 10.1002/pmic.201200415
DATABASE Protein 17 April 2022 (2022-04-17), ANONYMOUS : "microtubule-associated protein 2 isoform 1 [Homo sapiens]", XP093121997, retrieved from NCBI Database accession no. NP_001362434.1
PAJAK, B. ; SONGIN, M. ; STROSZNAJDER, J.B. ; GAJKOWSKA, B.: "Alzheimer's disease genetic mutation evokes ultrastructural alterations: Correlation to an intracellular A@b deposition and the level of GSK-3@b-P(Y216) phosphorylated form", NEUROTOXICOLOGY, TOX PRESS, RADFIELD, AR., IN, vol. 30, no. 4, 1 July 2009 (2009-07-01), IN , pages 581 - 588, XP026374870, ISSN: 0161-813X
DATABASE Protein 17 April 2022 (2022-04-17), ANONYMOUS : "microtubule-associated protein 2 isoform 1 [Homo sapiens]", XP093121997, retrieved from NCBI Database accession no. NP_001362434.1
PAJAK, B. ; SONGIN, M. ; STROSZNAJDER, J.B. ; GAJKOWSKA, B.: "Alzheimer's disease genetic mutation evokes ultrastructural alterations: Correlation to an intracellular A@b deposition and the level of GSK-3@b-P(Y216) phosphorylated form", NEUROTOXICOLOGY, TOX PRESS, RADFIELD, AR., IN, vol. 30, no. 4, 1 July 2009 (2009-07-01), IN , pages 581 - 588, XP026374870, ISSN: 0161-813X
Attorney, Agent or Firm:
HANOL INTELLECTUAL PROPERTY & LAW (KR)
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