METHOD FOR EFFICIENTLY PRODUCING 3D MIDBRAIN-LIKE ORGANOID THROUGH SPECIFIC ELECTROMAGNETIC WAVE PROCESSING

Title:

METHOD FOR EFFICIENTLY PRODUCING 3D MIDBRAIN-LIKE ORGANOID THROUGH SPECIFIC ELECTROMAGNETIC WAVE PROCESSING

Document Type and Number:

WIPO Patent Application WO/2018/124450

Kind Code:

A1

Abstract:

The present invention relates to a method for differentiating of 3D dopaminergic midbrain organoids by using specific electromagnetic waves. The method can significantly enhance the efficiency of production of dopamine neuron 3D differentiated organoids. It has been specifically confirmed that symptoms of Parkinson's disease can be effectively alleviated through the method. Consequently, it is expected that a more fundamental approach is possible for targeted treatment of a degenerative cranial nerve disorder.

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Inventors:

KIM JONGPIL (KR)
YOO JUNSANG (KR)

Application Number:

PCT/KR2017/012235

Publication Date:

July 05, 2018

Filing Date:

November 01, 2017

Export Citation:

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Assignee:

UNIV DONGGUK IND ACAD COOP (KR)

International Classes:

C12N5/079; A61K35/30; C12N13/00

Domestic Patent References:

WO2015135893A1

2015-09-17

Foreign References:

KR101472594B1

2014-12-15

Other References:

JADIDI, MAJID: "Mesenchymal stem cells that located in the electromagnetic fields improves rat model of Parkinson' s disease", IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, vol. 7, 19 July 2016 (2016-07-19), pages 741 - 748, XP055612894
JO, JUNGHYUN: "Midbrain-like organoids from human pluripotent stem cells contain functional dopaminergic and neuromelanin-producing neurons", CELL STEM CELL, vol. 19, no. 2, 4 August 2016 (2016-08-04), pages 248 - 257, XP029675877
BAEK, SOONBONG: "Electromagnetic fields mediate efficient cell reprogramming - into a pluripotent state", ACS NANO, vol. 8, no. 10, 10 August 2014 (2014-08-10), pages 10125 - 38, XP055612900

Attorney, Agent or Firm:

LEE, Myoung-Jin (KR)

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