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Title:
METHOD FOR ENHANCING THERAPEUTIC EFFECT OF CORNEAL ENDOTHELIAL CELL INJECTION THERAPY
Document Type and Number:
WIPO Patent Application WO/2022/025239
Kind Code:
A1
Abstract:
The present disclosure provides a composition for enhancing the therapeutic effect of cell injection therapy, said therapy aiming at treating or preventing a corneal endothelial symptom, disorder or disease. In one embodiment, the present disclosure provides a composition, which comprises a ROCK inhibitor, for enhancing the therapeutic effect of cell injection therapy, said therapy aiming at treating or preventing a corneal endothelial symptom, disorder or disease of a subject. This composition, which is to be used in combination with corneal endothelial cells and/or corneal endothelial-like cells, is characterized in that the composition is administered prior to the injection of the corneal endothelial cells and/or corneal endothelial-like cells into the anterior chamber of the subject. In some embodiments, the composition, etc. of the present disclosure are formulated into eye-drops.

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Inventors:
KOIZUMI NORIKO (JP)
OKUMURA NAOKI (JP)
MATSUOKA YASUSHI (JP)
Application Number:
PCT/JP2021/028299
Publication Date:
February 03, 2022
Filing Date:
July 30, 2021
Export Citation:
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Assignee:
THE DOSHISHA (JP)
ACTUALEYES INC (JP)
International Classes:
A61K45/00; A61K31/4409; A61K31/472; A61K31/506; A61K31/551; A61P27/02; A61P43/00; A61K35/30
Foreign References:
JP2019510509A2019-04-18
Other References:
KOIZUMI, NORIKO: "Development of Corneal Endothelium Regenerative Treatment Using Somatic Stem Cells", JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE, vol. 241, 30 November 2011 (2011-11-30), JP , pages 765 - 770, XP009533726, ISSN: 0039-2359
YUJI SAKAMOTO, NAOKI OKUMURA, NORIKO KOIZUMI, RYOUHEI NUMATA, JUNJI KITANO, MAYUMI YAMAMOTO, TAKAFUMI KOMADA, NOBUHIKO HOSHI: "Ferret animal model of corneal endothelial dysfunction for evaluation of drug effect on corneal endothelial wound healing", ANIMAL EYE RESEARCH, vol. 32, 1 January 2013 (2013-01-01), JP , pages 15 - 21, XP055421934, ISSN: 0286-7486, DOI: 10.11254/jscvo.32.15
Attorney, Agent or Firm:
YAMAMOTO, Shusaku et al. (JP)
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