METHOD OF EVALUATING ANTIOXIDATION ABILITY BY MEASURING REDOX BALANCE IN VIVO

Title:

METHOD OF EVALUATING ANTIOXIDATION ABILITY BY MEASURING REDOX BALANCE IN VIVO

Document Type and Number:

WIPO Patent Application WO/2003/091744

Kind Code:

A1

Abstract:

It is intended to provide a method of evaluating antioxidation ability by measuring redox balance in vivo wherein the redox balance is represented in accordance with the following formula: redox balance = (antioxidation index after administration/oxidation index after administration)/(antioxidation index before administration/ oxidation index before administration). Each antioxidation index is obtained by quantitatively measuring the attenuation rate of signal strength of DMPO-OOL radical, which arises by supplementing butylhydroperoxide radical with 5,5-dimethyl-1-pyrrloine-N-oxide (DMPO), caused by the addition of serum with the use of a magnetic resonance spinning device and then indexizing the thus obtained antioxidation ability in accordance with 10-rank distribution (1 to 10). ON the other hand, each oxidation index is obtained by quantifying urinary 8-hydroxydeoxyguanosine (8-OHdG) and then indexizing the thus obtained oxidation ability in accordance with 10-rank distribution (1 to 10).

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Inventors:

YOSHIKAWA TOSHIKAZU (JP)

Application Number:

PCT/JP2002/011469

Publication Date:

November 06, 2003

Filing Date:

November 01, 2002

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Assignee:

YOSHIKAWA TOSHIKAZU (JP)
MARIYAMA TOSHIKAZU (JP)
NAKAGAMI SHIZUO (JP)

International Classes:

G01N24/10; G01N33/02; G01N33/483; G01N33/493; G01N24/08; G01N33/50; G01N33/53; G01N33/577; (IPC1-7): G01R33/60; G01N24/10; G01N33/02

Foreign References:

JPH04169197A	1992-06-17
JPH04135484A	1992-05-08
JP2001200250A	2001-07-24
JP2002027929A	2002-01-29

Other References:

TORU TANIGAWA: "Determination of hydroxyl radical scavenging activity by electron spin resonance", JOURNAL OF KYOTO PREFECTURAL UNIVERSITY OF MEDICINE, vol. 99, no. 1, 1990, pages 133 - 143, XP002962361

Attorney, Agent or Firm:

Takeuchi, Sumio (6-21 Nishi-shimbashi 1-chom, Minato-ku Tokyo, JP)

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