Title:
METHOD FOR EVALUATING STATE OF CELL DIFFERENTIATION
Document Type and Number:
WIPO Patent Application WO/2021/014515
Kind Code:
A1
Abstract:
This invention relates to a method for evaluating the state of cell differentiation during the process of inducing differentiation from an induced pluripotent stem cell (iPS cell) to a retinal pigment epithelial cell. This invention further relates to a method for evaluating the state of cell differentiation during the process of inducing differentiation from an embryonic stem cell (ES cell) to a retinal pigment epithelial cell.
Inventors:
HARA KEISUKE (JP)
GOMI SHINICHI (JP)
NAGATA TOMOHISA (JP)
KAGAWA KENICHI (JP)
OSHIMA YASUHIRO (JP)
SUZUKI TAKASHI (JP)
TAKAHASHI MASATOSHI (JP)
YAMAMOTO TAKAKO (JP)
KAWAMATA SHIN (JP)
GOMI SHINICHI (JP)
NAGATA TOMOHISA (JP)
KAGAWA KENICHI (JP)
OSHIMA YASUHIRO (JP)
SUZUKI TAKASHI (JP)
TAKAHASHI MASATOSHI (JP)
YAMAMOTO TAKAKO (JP)
KAWAMATA SHIN (JP)
Application Number:
PCT/JP2019/028556
Publication Date:
January 28, 2021
Filing Date:
July 19, 2019
Export Citation:
Assignee:
TOKYO ELECTRON LTD (JP)
SHIMADZU CORP (JP)
FOUNDATION FOR BIOMEDICAL RES AND INNOVATION AT KOBE (JP)
SHIMADZU CORP (JP)
FOUNDATION FOR BIOMEDICAL RES AND INNOVATION AT KOBE (JP)
International Classes:
C12Q1/06; C12N5/071; C12N5/0735; G01N33/50; G01N33/68
Domestic Patent References:
| WO2017068727A1 | 2017-04-27 | |||
| WO2015166845A1 | 2015-11-05 | |||
| WO2014030749A1 | 2014-02-27 | |||
| WO2007069666A1 | 2007-06-21 |
Foreign References:
| JP2017504311A | 2017-02-09 |
Other References:
HIRAMI YOSAKADA FTAKAHASHI K ET AL.: "Generation of retinal cells from mouse and human induced pluripotent stem cells", NEUROSCI LETT, vol. 458, 2009, pages 126 - 131
KAMAO HMANDAI MOKAMOTO S ET AL.: "Characterization of human induced pluripotent stem cell-derived retinal pigment epithelium cell sheets aiming for clinical application", STEM CELL REPORTS, vol. 2, 2014, pages 205 - 218, XP055144196, DOI: 10.1016/j.stemcr.2013.12.007
KAMAO HMANDAI MWAKAMIYA S ET AL.: "Objective evaluation of the degree of pigmentation in human induced pluripotent stem cell-derived RPE", INVEST OPHTHALMOL VIS SCI., vol. 55, 2014, pages 8309 - 8318
LANE APHILIP LRRUBAN L ET AL.: "Engineering efficient retinal pigment epithelium differentiation from human pluripotent stem cells", STEM CELLS TRANSL MED, vol. 3, 2014, pages 1295 - 1304, XP055303892, DOI: 10.5966/sctm.2014-0094
VUGLER ACARR AJLAWRENCE J ET AL.: "Elucidating the phenomenon of HESC-derived RPE: anatomy of cell genesis, expansion and retinal transplantation", EXP NEUROL, vol. 214, 2008, pages 347 - 361, XP025695837, DOI: 10.1016/j.expneurol.2008.09.007
TAKAHASHI K.YAMANAKA D., CELL, vol. 126, 2006, pages 663 - 676
TAKAHASHI K. ET AL., CELL, vol. 131, 2007, pages 861 - 872
SUEMORI H. ET AL., BIOCHEM BIOPHYS RES COMMUN, vol. 345, 2006, pages 926 - 932
KAMAO HMANDAI MOKAMOTO S ET AL.: "Characterization of human induced pluripotent stem cell-derived retinal pigment epithelium cell sheets aiming for clinical application", STEM CELL REPORTS, vol. 2, 2014, pages 205 - 218, XP055144196, DOI: 10.1016/j.stemcr.2013.12.007
KAMAO HMANDAI MWAKAMIYA S ET AL.: "Objective evaluation of the degree of pigmentation in human induced pluripotent stem cell-derived RPE", INVEST OPHTHALMOL VIS SCI., vol. 55, 2014, pages 8309 - 8318
LANE APHILIP LRRUBAN L ET AL.: "Engineering efficient retinal pigment epithelium differentiation from human pluripotent stem cells", STEM CELLS TRANSL MED, vol. 3, 2014, pages 1295 - 1304, XP055303892, DOI: 10.5966/sctm.2014-0094
VUGLER ACARR AJLAWRENCE J ET AL.: "Elucidating the phenomenon of HESC-derived RPE: anatomy of cell genesis, expansion and retinal transplantation", EXP NEUROL, vol. 214, 2008, pages 347 - 361, XP025695837, DOI: 10.1016/j.expneurol.2008.09.007
TAKAHASHI K.YAMANAKA D., CELL, vol. 126, 2006, pages 663 - 676
TAKAHASHI K. ET AL., CELL, vol. 131, 2007, pages 861 - 872
SUEMORI H. ET AL., BIOCHEM BIOPHYS RES COMMUN, vol. 345, 2006, pages 926 - 932
Attorney, Agent or Firm:
SHA PATENT AND TRADEMARK (JP)
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