Title:
METHOD FOR EXTRACTING MYRICETIN FROM LIGNUM XANTHOCERAIS SORBIFOLIAE
Document Type and Number:
WIPO Patent Application WO/2023/227138
Kind Code:
A1
Abstract:
The present application relates to the technical field of extraction of active ingredients of traditional Chinese medicines. Provided in the present application is a method for extracting myricetin from Lignum xanthocerais sorbifoliae. The method comprises the following steps: S1, baking, crushing and sieving a medicinal material, i.e., Lignum xanthocerais sorbifoliae, to obtain a crude powder of Lignum xanthocerais sorbifoliae; S2, mixing the crude powder of Lignum xanthocerais sorbifoliae with a countercurrent leaching solution, and performing low-temperature countercurrent leaching to obtain a filtrate and a filter residue; S3, mixing the filter residue with a solvent, and heating same for reflux extraction 1-3 times to obtain an extracting solution; S4, combining the extracting solution and the filtrate obtained in S2, adding an alkaline auxiliary agent, adjusting the pH to 8-9, heating and boiling same, then cooling same to room temperature, and concentrating same under reduced pressure to obtain a concentrated solution; and S5, separating and eluting the concentrated solution in a macroporous adsorption resin using a monohydric alcohol aqueous solution, collecting the eluent, and drying same to obtain a myricetin solid. By means of the above-mentioned technical solution, the problems of low extraction rate and low purity of myricetin in the prior art are solved.
Inventors:
LI WEIJIA (CN)
ZHENG JINGMEI (CN)
YAN JINGYI (CN)
WANG JUNHUA (CN)
ZHENG JINGMEI (CN)
YAN JINGYI (CN)
WANG JUNHUA (CN)
Application Number:
PCT/CN2023/102795
Publication Date:
November 30, 2023
Filing Date:
June 27, 2023
Export Citation:
Assignee:
HEBEI RUILONG BIOTECHNOLOGY CO LTD (CN)
International Classes:
C07D311/30; C07D311/40
Foreign References:
| CN115260143A | 2022-11-01 | |||
| CN105535219A | 2016-05-04 | |||
| CN107721963A | 2018-02-23 | |||
| US20080058273A1 | 2008-03-06 |
Other References:
YANG QIAN; WANG XIAO-QIN; DING YAN-XIA: "Chemical constituents from the stems of Xanthoceras sorbifolia", CHINESE TRADITIONAL PATENT MEDICINE, GUOJIA YIYAO GUANLIJU, ZHONGCHENGYAO QINGBAO ZHONGXINZHAN, CN, vol. 42, no. 8, 31 August 2020 (2020-08-31), CN , pages 2062 - 2066, XP009550813, ISSN: 1001-1528, DOI: 10.3969/j.issn.1001-1528.2020.08.017
Attorney, Agent or Firm:
HEBEI GUOWEIZHIYUAN INTELLECTUAL PROPERTY AGENCY CO., LTD (CN)
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