Title:
METHOD FOR FABRICATING INTEGRATED MODEL OF FLEXIBLE HUMAN ESOPHAGUS, STOMACH, DUODENUM, AND SMALL INTESTINE, AND DYNAMIC IN VITRO BIOMIMETIC DIGESTIVE SYSTEM THEREOF
Document Type and Number:
WIPO Patent Application WO/2019/034008
Kind Code:
A1
Abstract:
Provided are a method for fabricating an integrated model of a flexible human esophagus, stomach, duodenum, and small intestine, and a dynamic in vitro biomimetic digestive system thereof. The method for preparation comprises scanning the internal and external structures of a human esophagus, stomach, duodenum, and small intestine to obtain a corresponding mold; applying a mold release agent evenly on the mold; pouring an elastic liquid material into the mold; waiting for same to cure, then releasing from the mold to separately obtain an esophagus model (a), stomach model (b), duodenum model (c), and small intestine model (d); cleaning the surfaces of same, then air-drying; using an adhesive to bond together, in sequence, the esophagus model (a), stomach model (b), duodenum model (c), and small intestine model (d) to obtain an integrated model; by means of a peristaltic pressing apparatus, applying pressure to the two sides of each of the esophagus model (a), stomach model (b), and duodenum model (c) to achieve biomimetic motion. It is thus possible to simulate the process of digestion of the human stomach and duodenum, providing accurate experimental data for research on the human digestive system while also appropriately reducing experimentation on animals and humans.
Inventors:
CHEN XIAODONG (CN)
LIAO ZHENKAI (CN)
LIU MINGHUI (CN)
WANG YONG (CN)
MENG JINFENG (CN)
DONG ZHIZHONG (CN)
LIAO ZHENKAI (CN)
LIU MINGHUI (CN)
WANG YONG (CN)
MENG JINFENG (CN)
DONG ZHIZHONG (CN)
Application Number:
PCT/CN2018/100122
Publication Date:
February 21, 2019
Filing Date:
August 11, 2018
Export Citation:
Assignee:
COFCO NUTRITION & HEALTH RES INST CO LTD (CN)
International Classes:
G09B23/28; G09B9/00
Foreign References:
| CN205318728U | 2016-06-15 | |||
| CN105702146A | 2016-06-22 | |||
| CN104464476A | 2015-03-25 | |||
| CN105224759A | 2016-01-06 | |||
| CN207852171U | 2018-09-11 | |||
| CN207367459U | 2018-05-15 | |||
| CN108081515A | 2018-05-29 | |||
| CN107452266A | 2017-12-08 |
Attorney, Agent or Firm:
QIANYUEIP INTELLECTUAL PROPERTY AGENCY (CN)
Download PDF:
Previous Patent: UNDERPANTS HAVING FRONT OPENING
Next Patent: Btk INHIBITORS WITH IMPROVED DUAL SELECTIVITY
Next Patent: Btk INHIBITORS WITH IMPROVED DUAL SELECTIVITY