Title:
METHOD OF GENE TRANSFER VIA VASCULAR SYSTEM OR URETER
Document Type and Number:
WIPO Patent Application WO/2002/083185
Kind Code:
A1
Abstract:
It is intended to provide a method of transferring a gene via vascular system or ureter. In a preferred embodiment, an aqueous solution containing an expression vector having a desired gene is injected $i(ex vivo) via the vascular system of a desired organ or ureter and thus the desired gene is transferred into the injected region. This method is particularly useful in an $i(ex vivo) gene therapy wherein hepatocyte growth factor (HGF) gene is transferred into a transplanted kidney by using the electroporation method. By using this method, it is possible to make HGF to continuously exert its effect not on the organs in the whole body but exclusively on the transplanted kidney. Thus, it is a safe and effective therapy of protecting the take of the transplanted kidney.
Inventors:
TAKAHARA SHIRO (JP)
IMAI ENYU (JP)
ISAKA YOSHITAKA (JP)
IMAI ENYU (JP)
ISAKA YOSHITAKA (JP)
Application Number:
PCT/JP2002/002770
Publication Date:
October 24, 2002
Filing Date:
March 22, 2002
Export Citation:
Assignee:
CHUGAI PHARMACEUTICAL CO LTD (JP)
TAKAHARA SHIRO (JP)
IMAI ENYU (JP)
ISAKA YOSHITAKA (JP)
TAKAHARA SHIRO (JP)
IMAI ENYU (JP)
ISAKA YOSHITAKA (JP)
International Classes:
A61K35/76; A61K38/18; A61K48/00; A61L27/14; A61L27/36; A61L27/54; A61P13/12; A61P37/06; C07K14/475; (IPC1-7): A61K48/00; A61P13/12; A61P37/06
Domestic Patent References:
| WO2000022095A2 | 2000-04-20 | |||
| WO1996030535A1 | 1996-10-03 | |||
| WO2002000264A1 | 2002-01-03 |
Foreign References:
| FR2717500A1 | 1995-09-22 | |||
| EP0462549A1 | 1991-12-27 |
Other References:
YOSHITAKA ISAKA ET AL.: "Ishoku jin no choki seichaku o mezashita idenshi chiryo", THE JAPANESE SOCIETY OF NEPHROLOGY, 22 March 2001 (2001-03-22), XP002954958, Retrieved from the Internet [retrieved on 20020409]
ENYU IMAI ET AL.: "Jin shikkan no idenshi chiryo ha dokomade kano ka", KIDNEY AND DIALYSIS, vol. 49, no. 6, 2000, pages 1021 - 1024, XP002954950
ENYU IMAI ET AL.: "Jin shikkan oyobi jin ishoku (post genome iryo no tenbo: soron)", NIHON RINSHO, vol. 59, no. 1, 1 January 2001 (2001-01-01), pages 65 - 71, XP002954949
ENYU IMAI ET AL.: "Jin shikkan no idenshi chiryo no kanosei to sono genjo", JOURNAL OF OSAKA SOCIETY FOR DIALYSIS THERAPY, vol. 18, no. 2, 2000, pages 193 - 197, XP002954948
ENYU IMAI ET AL.: "Jin eno idenshi donyu to idenshi chiryo", IGAKU NO AYUMI, vol. 193, no. 1, 1 April 2000 (2000-04-01), pages 87 - 90, XP002954951
MICHIKO TSUJIE ET AL.: "Electroporation ho o mochiita jin shikyutai eno idenshi donyu ho no kaihatsu", THE JAPANESE JOURNAL OF NEPHROLOGY, vol. 42, no. 3, 25 April 2000 (2000-04-25), (THE JAPANESE SOCIETY OF NEPHROLOGY GAKUJUTSU SOKAI SHOROKUSHU, ABSTRACT NO. 0-256), pages 198, XP002954954
HIROYUKI NAKAMURA ET AL.: "Electroporation ho o mochiita Egr-1 DNA enzyme donyu ni yoru jinkanshitsu shogai shinten no yokusei", TJE JAPANESE SOCIETY OF NEPHROLOGY, 22 March 2001 (2001-03-22), XP002954959, Retrieved from the Internet [retrieved on 20020409]
DATABASE MEDLINE [online] IMAI E. ET AL.: "Gene therapy for kidney disease", accession no. STN Database accession no. 20516053
DATABASE MEDLINE [online] TSUJIE M. ET AL.: "Gene transfer targeting interstitial fibroblasts by the artificial viral envelope-type hemagglutinating virus of Japan liposome method", accession no. STN Database accession no. 20253278
SHINYA MIZUNO ET AL.: "Ishoku igaku ni okeru HGF no yakuwari", IGAKU NO AYUMI, vol. 196, no. 13, 31 March 2001 (2001-03-31), pages 905 - 912, XP002954953
HARUTO AZUMA ET AL.: "Hepatocyte growth factor (HGF) no mansei kyozetsu hanno (rat ishoku jin) ni taisuru chiryo koka", THE JAPANESE JOURNAL OF UROLOGY, vol. 90, no. 2, 8 February 1999 (1999-02-08), (THE 87TH ANNUAL MEETING OF THE JAPANESE UROLOGICAL ASSOCIATION, ABSTRACT NO. 0-163), pages 150, XP002954955
HARUTO AZUMA ET AL.: "Hepatocyte growth factor (HGF) no mansei kyuozetsu hannu (rat ishoku jin) ni taisuru chiryo koka", THE JAPANESE JOURNAL OF UROLOGY, vol. 92, no. 2, 20 February 2001 (2001-02-20), (THE 89TH ANNUAL MEETING OF THE JAPANESE UROLOGICAL ASSOCIATION, ABSTRACT NO. MP-17), pages 184, XP002954956
YOSHITAKA ISAKA ET AL.: "Ishoku jin no choki seichaku o mezashita idenshi chiryo", THE JAPANESE JOURNAL OF NEPHROLOGY, vol. 43, no. 3, 25 April 2001 (2001-04-25), (DAI 44 KAI (HEISEI 13 NENDO 2001) THE JAPANESE SOCIETY OF NEPHROLOGY GAKUJUTSU SOKAI SHOROKUSHU, ABSTRACT NO. W-5-4), pages 164, XP002954957
MARUYAMA H. ET AL.: "Kidney-targeted maked DNA transfer by retrograde renal vein injection in rats", HUMAN GENE THERAPY, vol. 13, no. 3, 10 February 2002 (2002-02-10), pages 455 - 468, XP002955053
DATABASE MEDLINE [online] DAI C. ET AL.: "Single injection of naked plasmid encoding hepatocyte growth factor prevents cell death and ameliorates acute renal failure in mice", accession no. STN Database accession no. 21663895
HIROYUKI NAKAMURA ET AL.: "Electroporation ho o mochiita Egr-1 DNA enzyme donyu ni yoru jinkansitsu shogai shinten no yokusei", THE JAPANESE JOURNAL OF NEPHROLOGY, vol. 43, no. 3, 25 April 2001 (2001-04-25), (DAI 44 KAI (HEISEI 13 NENDO 2001) THE JAPANESE SOCIETY OF NEPHROLOGY GAKUJUTSU SOKAI SHOROKUSHU, ABSTRACT NO. 0-142), pages 189
TSUJIE M. ET AL.: "Electroporation-mediated gene transfer that targets glomeruli", J. AM. SOC. NEPHROL., vol. 12, 2001, pages 949 - 954, XP002954952
DATABASE MEDLINE [online] IMAI E. ET AL.: "Gene electrotransfer: Potential for gene therapy of renal diseases", accession no. STN Database accession no. 21830998
ENYU IMAI ET AL.: "Jin shikkan no idenshi chiryo ha dokomade kano ka", KIDNEY AND DIALYSIS, vol. 49, no. 6, 2000, pages 1021 - 1024, XP002954950
ENYU IMAI ET AL.: "Jin shikkan oyobi jin ishoku (post genome iryo no tenbo: soron)", NIHON RINSHO, vol. 59, no. 1, 1 January 2001 (2001-01-01), pages 65 - 71, XP002954949
ENYU IMAI ET AL.: "Jin shikkan no idenshi chiryo no kanosei to sono genjo", JOURNAL OF OSAKA SOCIETY FOR DIALYSIS THERAPY, vol. 18, no. 2, 2000, pages 193 - 197, XP002954948
ENYU IMAI ET AL.: "Jin eno idenshi donyu to idenshi chiryo", IGAKU NO AYUMI, vol. 193, no. 1, 1 April 2000 (2000-04-01), pages 87 - 90, XP002954951
MICHIKO TSUJIE ET AL.: "Electroporation ho o mochiita jin shikyutai eno idenshi donyu ho no kaihatsu", THE JAPANESE JOURNAL OF NEPHROLOGY, vol. 42, no. 3, 25 April 2000 (2000-04-25), (THE JAPANESE SOCIETY OF NEPHROLOGY GAKUJUTSU SOKAI SHOROKUSHU, ABSTRACT NO. 0-256), pages 198, XP002954954
HIROYUKI NAKAMURA ET AL.: "Electroporation ho o mochiita Egr-1 DNA enzyme donyu ni yoru jinkanshitsu shogai shinten no yokusei", TJE JAPANESE SOCIETY OF NEPHROLOGY, 22 March 2001 (2001-03-22), XP002954959, Retrieved from the Internet
DATABASE MEDLINE [online] IMAI E. ET AL.: "Gene therapy for kidney disease", accession no. STN Database accession no. 20516053
DATABASE MEDLINE [online] TSUJIE M. ET AL.: "Gene transfer targeting interstitial fibroblasts by the artificial viral envelope-type hemagglutinating virus of Japan liposome method", accession no. STN Database accession no. 20253278
SHINYA MIZUNO ET AL.: "Ishoku igaku ni okeru HGF no yakuwari", IGAKU NO AYUMI, vol. 196, no. 13, 31 March 2001 (2001-03-31), pages 905 - 912, XP002954953
HARUTO AZUMA ET AL.: "Hepatocyte growth factor (HGF) no mansei kyozetsu hanno (rat ishoku jin) ni taisuru chiryo koka", THE JAPANESE JOURNAL OF UROLOGY, vol. 90, no. 2, 8 February 1999 (1999-02-08), (THE 87TH ANNUAL MEETING OF THE JAPANESE UROLOGICAL ASSOCIATION, ABSTRACT NO. 0-163), pages 150, XP002954955
HARUTO AZUMA ET AL.: "Hepatocyte growth factor (HGF) no mansei kyuozetsu hannu (rat ishoku jin) ni taisuru chiryo koka", THE JAPANESE JOURNAL OF UROLOGY, vol. 92, no. 2, 20 February 2001 (2001-02-20), (THE 89TH ANNUAL MEETING OF THE JAPANESE UROLOGICAL ASSOCIATION, ABSTRACT NO. MP-17), pages 184, XP002954956
YOSHITAKA ISAKA ET AL.: "Ishoku jin no choki seichaku o mezashita idenshi chiryo", THE JAPANESE JOURNAL OF NEPHROLOGY, vol. 43, no. 3, 25 April 2001 (2001-04-25), (DAI 44 KAI (HEISEI 13 NENDO 2001) THE JAPANESE SOCIETY OF NEPHROLOGY GAKUJUTSU SOKAI SHOROKUSHU, ABSTRACT NO. W-5-4), pages 164, XP002954957
MARUYAMA H. ET AL.: "Kidney-targeted maked DNA transfer by retrograde renal vein injection in rats", HUMAN GENE THERAPY, vol. 13, no. 3, 10 February 2002 (2002-02-10), pages 455 - 468, XP002955053
DATABASE MEDLINE [online] DAI C. ET AL.: "Single injection of naked plasmid encoding hepatocyte growth factor prevents cell death and ameliorates acute renal failure in mice", accession no. STN Database accession no. 21663895
HIROYUKI NAKAMURA ET AL.: "Electroporation ho o mochiita Egr-1 DNA enzyme donyu ni yoru jinkansitsu shogai shinten no yokusei", THE JAPANESE JOURNAL OF NEPHROLOGY, vol. 43, no. 3, 25 April 2001 (2001-04-25), (DAI 44 KAI (HEISEI 13 NENDO 2001) THE JAPANESE SOCIETY OF NEPHROLOGY GAKUJUTSU SOKAI SHOROKUSHU, ABSTRACT NO. 0-142), pages 189
TSUJIE M. ET AL.: "Electroporation-mediated gene transfer that targets glomeruli", J. AM. SOC. NEPHROL., vol. 12, 2001, pages 949 - 954, XP002954952
DATABASE MEDLINE [online] IMAI E. ET AL.: "Gene electrotransfer: Potential for gene therapy of renal diseases", accession no. STN Database accession no. 21830998
Attorney, Agent or Firm:
Shimizu, Hatsushi (1-1-1 Oroshi-mach, Tsuchiura-shi Ibaraki, JP)
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