Title:
METHOD FOR GLYCOSYLATION MODIFICATION OF PROTEINS AND/OR POLYPEPTIDES
Document Type and Number:
WIPO Patent Application WO/2024/050809
Kind Code:
A1
Abstract:
Provided is a method for the glycosylation modification of proteins and/or polypeptides, belonging to the technical field of medicinal chemistry. Using glycosyl sulfinate as a raw material, a method for the glycosylation modification of proteins and/or polypeptides is provided. Reaction raw materials of the present method are easy to obtain, the reaction conditions are mild, the reaction time is short, and the reaction process is controllable. The obtained glycosylation-modified proteins and/or polypeptides have high yield and high purity. The method for glycosylation modification is applicable not only to proteins and/or peptides containing disulfide bonds, but also to proteins and/or peptides containing sulfhydryl groups. The method is even applicable to proteins and/or peptides containing both disulfide bonds and sulfhydryl groups. The application prospects are broad.
More Like This:
| WO/2016/074531 | METHOD FOR PREPARING SOFOSBUVIR |
| WO/1997/042502 | CELL WALL ASSAY |
| WO/2004/065400 | NOVEL BINDING EPITOPES FOR HELICOBACTER PYLORI AND USE THEREOF |
Inventors:
NIU DAWEN (CN)
ZHANG XIA (CN)
ZHANG CHEN (CN)
ZUO HAO (CN)
ZENG HONGXIN (CN)
LI YANJING (CN)
WANG JIAXI (CN)
REN HAIYAN (CN)
ZHANG XIA (CN)
ZHANG CHEN (CN)
ZUO HAO (CN)
ZENG HONGXIN (CN)
LI YANJING (CN)
WANG JIAXI (CN)
REN HAIYAN (CN)
Application Number:
PCT/CN2022/118051
Publication Date:
March 14, 2024
Filing Date:
September 09, 2022
Export Citation:
Assignee:
UNIV SICHUAN (CN)
International Classes:
C07H1/00; A01N41/04; C07D513/04; C07H5/10; C07H9/04; C07K7/06
Foreign References:
| CN114736248A | 2022-07-12 | |||
| CN112279880A | 2021-01-29 | |||
| US20070213506A1 | 2007-09-13 | |||
| CN114375295A | 2022-04-19 |
Other References:
ZHANG GAO-LAN, GADI MADHUSUDHAN REDDY, CUI XIKAI, LIU DING, ZHANG JIABIN, SAIKAM VARMA, GIBBONS CHRISTOPHER, WANG PENG G., LI LEI: "Protecting-group-free S -glycosylation towards thioglycosides and thioglycopeptides in water", GREEN CHEMISTRY, ROYAL SOCIETY OF CHEMISTRY, GB, vol. 23, no. 8, 26 April 2021 (2021-04-26), GB , pages 2907 - 2912, XP093148629, ISSN: 1463-9262, DOI: 10.1039/D1GC00098E
ROMANÒ CECILIA, JIANG HAO, BOOS IRENE, CLAUSEN MADS H.: "S -Glycosides: synthesis of S -linked arabinoxylan oligosaccharides", ORGANIC & BIOMOLECULAR CHEMISTRY, ROYAL SOCIETY OF CHEMISTRY, vol. 18, no. 14, 8 April 2020 (2020-04-08), pages 2696 - 2701, XP093148631, ISSN: 1477-0520, DOI: 10.1039/D0OB00470G
ROMANÒ CECILIA, JIANG HAO, BOOS IRENE, CLAUSEN MADS H.: "S -Glycosides: synthesis of S -linked arabinoxylan oligosaccharides", ORGANIC & BIOMOLECULAR CHEMISTRY, ROYAL SOCIETY OF CHEMISTRY, vol. 18, no. 14, 8 April 2020 (2020-04-08), pages 2696 - 2701, XP093148631, ISSN: 1477-0520, DOI: 10.1039/D0OB00470G
Attorney, Agent or Firm:
GAOYUNG INTELLECTUAL PROPERTY AGENCY (GENERAL PARTNERSHIP) (CN)
Download PDF:
Previous Patent: POINTING DEVICE WITH FLEXIBLE SLEEVE
Next Patent: BINDER COMPOSITION AND ELECTRODE SHEET PREPARED FROM SAME
Next Patent: BINDER COMPOSITION AND ELECTRODE SHEET PREPARED FROM SAME