Title:
METHOD FOR IDENTIFYING NOVEL TREATMENTS OF INFLAMMATORY DISEASE IN THE GUT
Document Type and Number:
WIPO Patent Application WO2004066909
Kind Code:
A3
Abstract:
Model fish and use thereof for screening for the presence of gut inflammatory disease, especially in zebrafish. Induction of the disease state and visualization of the gastrointestinal tract in living zebrafish. Visualization of the inflammatory state in vivo facilitates screening for compounds that can be used in treatment of inflammatory disease of the gut or genetic mutations that rescue or suppress the disease phenotype.
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Inventors:
GOLDSMITH PAUL (GB)
FLEMING ANGELEEN LOUISE (GB)
FLEMING ANGELEEN LOUISE (GB)
Application Number:
PCT/GB2004/000349
Publication Date:
September 23, 2004
Filing Date:
January 28, 2004
Export Citation:
Assignee:
DANIOLABS LTD (GB)
GOLDSMITH PAUL (GB)
FLEMING ANGELEEN LOUISE (GB)
GOLDSMITH PAUL (GB)
FLEMING ANGELEEN LOUISE (GB)
International Classes:
A01K67/027; A61P1/00; C12N15/85; (IPC1-7): A01K67/027; A01B5/00; A61P1/00
Other References:
FARBER S.A. ET AL: "Genetic analysis of digestive physiology using fluorescent phospholipid reporters", SCIENCE, no. 292, 18 May 2001 (2001-05-18), pages 1385 - 1388, XP002288778
MUELLER T. & WULIMANN M.F.: "BrdU- neurodD (nrd)- and Hu-studies reveal unusual non-ventricula neurogenesis in the postembryonic zebrafish forebrain", MECHANISMS OF DEVELOPMENT, vol. 117, 2002, pages 123 - 135, XP002288780
VILLEGAS, I. ET AL: "Effects of dosmalfate, a new cytoprotective agent, on acute and chronic trinitrobenzene sulphonic acid-induced colitis in rats", EUROPEAN JOURNAL OF PHARMACOLOGY, vol. 460, 24 January 2003 (2003-01-24), pages 209 - 218, XP002288779
KIM H S ET AL: "Experimental colitis in animal models", MEDLINE, 1992, XP002182457
MUELLER T. & WULIMANN M.F.: "BrdU- neurodD (nrd)- and Hu-studies reveal unusual non-ventricula neurogenesis in the postembryonic zebrafish forebrain", MECHANISMS OF DEVELOPMENT, vol. 117, 2002, pages 123 - 135, XP002288780
VILLEGAS, I. ET AL: "Effects of dosmalfate, a new cytoprotective agent, on acute and chronic trinitrobenzene sulphonic acid-induced colitis in rats", EUROPEAN JOURNAL OF PHARMACOLOGY, vol. 460, 24 January 2003 (2003-01-24), pages 209 - 218, XP002288779
KIM H S ET AL: "Experimental colitis in animal models", MEDLINE, 1992, XP002182457
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