Title:
METHOD FOR IDENTIFYING TARGET EPITOPES OF THE T CELL MEDIATED IMMUNE RESPONSE AND FOR ASSAYING EPITOPE-SPECIFIC T CELLS
Document Type and Number:
WIPO Patent Application WO2003046212
Kind Code:
A3
Abstract:
The invention relates to a method for assaying epitope-specific T cells and target epitopes of reactive T cells. The present invention further relates to vectors, comprising a first promoter that can be specifically induced in antigen-presenting cells by the epitope-specific contact with a T cell, a nucleic acid functionally linked with said first promoter and encoding a marker gene, a second promoter that is constitutive in antigen-presenting cells, and a nucleic acid that is functionally linked with said second promoter. The present invention further relates to antigen-presenting cells that are transduced with the vectors according to the invention.
Inventors:
DEML LUDWIG (DE)
Application Number:
PCT/DE2002/004270
Publication Date:
November 27, 2003
Filing Date:
November 20, 2002
Export Citation:
Assignee:
DEML LUDWIG (DE)
International Classes:
C07K14/705; C12N15/10; C12N15/85; G01N33/50; G01N33/68; (IPC1-7): C12N15/85; C12N5/10; G01N33/50
Domestic Patent References:
| WO2000057705A1 | 2000-10-05 | |||
| WO2001032204A2 | 2001-05-10 | |||
| WO2000067761A1 | 2000-11-16 |
Other References:
TAKAYAMA T ET AL: "TRANSDUCTION OF DENDRITIC CELL PROGENITORS WITH A RETROVIRAL VECTOR ENCODING VIRAL INTERLEUKIN-10 AND ENHANCED GREEN FLUORESCENT PROTEIN ALLOWS PURIFICATION OF POTENTIALLY TOLEROGENIC ANTIGEN-PRESENTING CELLS", TRANSPLANTATION, vol. 68, no. 12, 27 December 1999 (1999-12-27), pages 1903 - 1909, XP000943559, ISSN: 0041-1337
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