Title:
METHOD FOR IMMUNOSTIMULATION USING BINDING AGENTS FOR THE FC REC EPTOR OF IMMUNOGLOBULIN A AND FOR CANCER CELLS OR INFECTIONS ANTIGEN
Document Type and Number:
WIPO Patent Application WO2001072330
Kind Code:
A3
Abstract:
Methods and compositions for eliminating pathogens from the circulatory system of a subject are disclosed. These methods rely on the interaction between monomeric (serum) IgA and Fc alpha RI expressed on liver Kupffer cells. The methods employ therapeutic complexes which are made up of a first portion which specifically binds Fc alpha RI expressed on liver Kupffer cells, or which specifically binds monomeric IgA or the Fc region thereof, linked to a second portion which specifically binds the target cell or antigen.
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Inventors:
VAN DE WINKEL JAN G J (NL)
Application Number:
PCT/US2001/009816
Publication Date:
March 07, 2002
Filing Date:
March 27, 2001
Export Citation:
Assignee:
MEDAREX INC (US)
WINKEL JAN G J VAN DE (NL)
WINKEL JAN G J VAN DE (NL)
International Classes:
A61K39/395; A61P31/00; A61P35/00; A61K38/00; C07K16/08; C07K16/28; C07K16/30; (IPC1-7): A61K39/395; A61P35/00; A61P31/00
Other References:
DEO Y ET AL: "Bispecific molecules directed to the Fc receptor for IgA (FcalphaRI, CD89) and tumor antigens efficiently promote cell-mediated cytotoxicity of tumor targets in whole blood", JOURNAL OF IMMUNOLOGY, THE WILLIAMS AND WILKINS CO. BALTIMORE, US, vol. 4, no. 160, 15 February 1998 (1998-02-15), pages 1677 - 1686, XP002077127, ISSN: 0022-1767
ELSASSER D ET AL: "PRECLINICAL STUDIES COMBINING BISPECIFIC ANTIBODIES WITH CYTOKINE-STIMULATED EFFECTOR CELLS FOR IMMUNOTHERAPY OF RENAL CELL CARCINOMA", ANTICANCER RESEARCH, HELENIC ANTICANCER INSTITUTE, ATHENS,, GR, vol. 19, no. 2C, March 1999 (1999-03-01), pages 1525 - 1528, XP000944311, ISSN: 0250-7005
VALERIUS T ET AL: "FCALPHARI (CD89) AS A NOVEL TRIGGER MOLECULE FOR BISPECIFIC ANTIBODY THERAPY", BLOOD, W.B. SAUNDERS, PHILADELPHIA, VA, US, vol. 90, no. 11, 1 December 1997 (1997-12-01), pages 4485 - 4492, XP000973061, ISSN: 0006-4971
HULS G ET AL: "ANTITUMOR IMMUNE EFFECTOR MECHANISMS RECRUITED BY PHAGE DISPLAY-DERIVED FULLY HUMAN IGG1 AND IGA1 MONOCLONAL ANTIBODIES", CANCER RESEARCH, AMERICAN ASSOCIATION FOR CANCER RESEARCH, BALTIMORE, MD, US, vol. 59, no. 22, 15 November 1999 (1999-11-15), pages 5778 - 5784, XP000941614, ISSN: 0008-5472
LEE H PAI ET AL: "Anti-tumor activities of immunotoxins made of monoclonal antibody B3 and various forms of Pseudomonas exotoxin", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF USA, NATIONAL ACADEMY OF SCIENCE. WASHINGTON, US, vol. 88, April 1991 (1991-04-01), pages 3358 - 3362, XP002125579, ISSN: 0027-8424
VAN EGMOND M ET AL: "FcalphaRI -positive liver Kupffer cells: reappraisal of the function of immunoglobulin A in immunity.", NATURE MEDICINE, (2000 JUN) 6 (6) 680-5., XP002177547
ELSASSER D ET AL: "PRECLINICAL STUDIES COMBINING BISPECIFIC ANTIBODIES WITH CYTOKINE-STIMULATED EFFECTOR CELLS FOR IMMUNOTHERAPY OF RENAL CELL CARCINOMA", ANTICANCER RESEARCH, HELENIC ANTICANCER INSTITUTE, ATHENS,, GR, vol. 19, no. 2C, March 1999 (1999-03-01), pages 1525 - 1528, XP000944311, ISSN: 0250-7005
VALERIUS T ET AL: "FCALPHARI (CD89) AS A NOVEL TRIGGER MOLECULE FOR BISPECIFIC ANTIBODY THERAPY", BLOOD, W.B. SAUNDERS, PHILADELPHIA, VA, US, vol. 90, no. 11, 1 December 1997 (1997-12-01), pages 4485 - 4492, XP000973061, ISSN: 0006-4971
HULS G ET AL: "ANTITUMOR IMMUNE EFFECTOR MECHANISMS RECRUITED BY PHAGE DISPLAY-DERIVED FULLY HUMAN IGG1 AND IGA1 MONOCLONAL ANTIBODIES", CANCER RESEARCH, AMERICAN ASSOCIATION FOR CANCER RESEARCH, BALTIMORE, MD, US, vol. 59, no. 22, 15 November 1999 (1999-11-15), pages 5778 - 5784, XP000941614, ISSN: 0008-5472
LEE H PAI ET AL: "Anti-tumor activities of immunotoxins made of monoclonal antibody B3 and various forms of Pseudomonas exotoxin", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF USA, NATIONAL ACADEMY OF SCIENCE. WASHINGTON, US, vol. 88, April 1991 (1991-04-01), pages 3358 - 3362, XP002125579, ISSN: 0027-8424
VAN EGMOND M ET AL: "FcalphaRI -positive liver Kupffer cells: reappraisal of the function of immunoglobulin A in immunity.", NATURE MEDICINE, (2000 JUN) 6 (6) 680-5., XP002177547
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