Title:
METHOD OF IMPROVING BLOOD KINETICS OF PEPTIDE
Document Type and Number:
WIPO Patent Application WO/2020/095922
Kind Code:
A1
Abstract:
A method of improving the blood kinetics of a peptide is provided. This method of improving blood kinetics of a peptide involves a step for preparing a peptide having a modified amino acid sequence.
Inventors:
NISHIMIYA DAISUKE (JP)
YANO HIDENORI (JP)
YANO HIDENORI (JP)
Application Number:
PCT/JP2019/043386
Publication Date:
May 14, 2020
Filing Date:
November 06, 2019
Export Citation:
Assignee:
DAIICHI SANKYO CO LTD (JP)
International Classes:
A61K39/395; A61K38/17; A61K38/55; A61K47/68; A61P1/04; A61P11/06; A61P17/00; A61P17/06; A61P35/00; A61P37/08; A61P43/00
Domestic Patent References:
| WO2014024914A1 | 2014-02-13 | |||
| WO2019049933A1 | 2019-03-14 | |||
| WO2014024914A1 | 2014-02-13 | |||
| WO2018117244A1 | 2018-06-28 | |||
| WO2019017338A1 | 2019-01-24 | |||
| WO2019049933A1 | 2019-03-14 | |||
| WO1988007089A1 | 1988-09-22 | |||
| WO1994028027A1 | 1994-12-08 | |||
| WO1994029351A2 | 1994-12-22 |
Foreign References:
| JP4750718B2 | 2011-08-17 |
Other References:
CHUNG, H. S. ET AL.: "The N-terminal alanine- extended GLP-1/1gG-Fc fusion protein confers resistance to DPP-IV and reduces serum glucose level in db/db mice", REGUL PEPT, vol. 170, 2011, pages 1 - 3, XP055523607, DOI: 10.1016/j.regpep.2011.05.002
KWON, Y. T. ET AL.: "Alternatlve splicing results in differential expression, activity, and localization of the two forms of arginyl-tRNA- protein transferase, a component of N-end rule pathway", MOL CELL BIOL, vol. 19, no. 1, 1999, pages 182 - 193, XP002968933
USMANI SS ET AL., PLOS ONE, vol. 12, no. 7, 2017, pages e0181748
STROHL WR ET AL., BIODRUGS, vol. 29, no. 4, 2015, pages 215 - 239
LIU L ET AL., PROTEIN CELL, vol. 9, no. 1, 2018, pages 15 - 32
UNVERDORBEN F ET AL., MABS, vol. 8, no. 1, 2016, pages 120 - 128
SAXENA A ET AL., FRONT IMMUNOL, vol. 7, 2016, pages 580
CHEN T ET AL., PROTEINS, vol. 77, no. 1, 2009, pages 209 - 219
L. LEHNINGER: "Biochemistry", 1975, WORTH PUBLISHER, pages: 73 - 75
BRUGGEMANN ET AL., J. EXP. MED., 1987, pages 1351 - 1361
ANGAL ET AL., MOL. IMMUNOL., vol. 30, 1993, pages 105 - 108
PAREKH ET AL., MABS, 2012, pages 310 - 318
SAMBROOK, J.FRITSCH, E.F.MANIATIS, T.: "Molecular Cloning", 1982, COLD SPRING HARBOR LABORATORY PRESS
See also references of EP 3878469A4
KWON, Y. T. ET AL.: "Alternatlve splicing results in differential expression, activity, and localization of the two forms of arginyl-tRNA- protein transferase, a component of N-end rule pathway", MOL CELL BIOL, vol. 19, no. 1, 1999, pages 182 - 193, XP002968933
USMANI SS ET AL., PLOS ONE, vol. 12, no. 7, 2017, pages e0181748
STROHL WR ET AL., BIODRUGS, vol. 29, no. 4, 2015, pages 215 - 239
LIU L ET AL., PROTEIN CELL, vol. 9, no. 1, 2018, pages 15 - 32
UNVERDORBEN F ET AL., MABS, vol. 8, no. 1, 2016, pages 120 - 128
SAXENA A ET AL., FRONT IMMUNOL, vol. 7, 2016, pages 580
CHEN T ET AL., PROTEINS, vol. 77, no. 1, 2009, pages 209 - 219
L. LEHNINGER: "Biochemistry", 1975, WORTH PUBLISHER, pages: 73 - 75
BRUGGEMANN ET AL., J. EXP. MED., 1987, pages 1351 - 1361
ANGAL ET AL., MOL. IMMUNOL., vol. 30, 1993, pages 105 - 108
PAREKH ET AL., MABS, 2012, pages 310 - 318
SAMBROOK, J.FRITSCH, E.F.MANIATIS, T.: "Molecular Cloning", 1982, COLD SPRING HARBOR LABORATORY PRESS
See also references of EP 3878469A4
Attorney, Agent or Firm:
ISHIBASHI Koki et al. (JP)
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