Title:
METHOD FOR IMPROVING SAFETY OF DRUG CONTAINING IMMUNOGLOBULIN FC FRAGMENT
Document Type and Number:
WIPO Patent Application WO/2022/188867
Kind Code:
A1
Abstract:
Provided is a method for optimizing a drug containing an immunoglobulin Fc fragment to improve the safety and/or efficacy of the drug. Specifically, provided is a method for reducing or blocking the level of IL-8 and/or IL-6 secreted by an immune cell mediated by a drug containing an immunoglobulin Fc fragment. The method can effectively improve the safety and/or efficacy of the drug containing the immunoglobulin Fc fragment.
Inventors:
ZHANG PENG (CN)
LI BAIYONG (CN)
XIA YU (CN)
WANG ZHONGMIN (CN)
LI BAIYONG (CN)
XIA YU (CN)
WANG ZHONGMIN (CN)
Application Number:
PCT/CN2022/080392
Publication Date:
September 15, 2022
Filing Date:
March 11, 2022
Export Citation:
Assignee:
AKESO BIOPHARMA INC (CN)
International Classes:
A61P35/00; A61K39/395; C07K16/46
Domestic Patent References:
| WO2021213475A1 | 2021-10-28 | |||
| WO2021023117A1 | 2021-02-11 |
Foreign References:
| CN112300286A | 2021-02-02 | |||
| CN112300280A | 2021-02-02 | |||
| CN106967172A | 2017-07-21 | |||
| CN105793287A | 2016-07-20 |
Other References:
LISA T. C. VOGELPOEL, BAETEN DOMINIQUE L. P., DE JONG ESTHER C., DEN DUNNEN JEROEN: "Control of cytokine production by human Fc gamma receptors: implications for pathogen defense and autoimmunity", FRONTIERS IN IMMUNOLOGY, vol. 6, pages 1 - 11, XP055312134, DOI: 10.3389/fimmu.2015.00079
FINCO D., GRIMALDI C., FORT M., WALKER M., KIESSLING A., WOLF B., SALCEDO T., FAGGIONI R., SCHNEIDER A., IBRAGHIMOV A., SCESNEY S.: "Cytokine release assays: Current practices and future directions", CYTOKINE, ACADEMIC PRESS LTD, PHILADELPHIA, PA, US, vol. 66, no. 2, 1 April 2014 (2014-04-01), US , pages 143 - 155, XP055964902, ISSN: 1043-4666, DOI: 10.1016/j.cyto.2013.12.009
XINHUA WANG, MARY MATHIEU, RANDALL J. BREZSKI: "IgG Fc engineering to modulate antibody effector functions", PROTEIN & CELL, SPRINGER ASIA, BEIJING, CN, vol. 9, no. 1, 1 January 2018 (2018-01-01), Beijing, CN , pages 63 - 73, XP055457296, ISSN: 1674-800X, DOI: 10.1007/s13238-017-0473-8
LI B., Z. HUANG, X. PANG, T. ZHONG, C. JIN, N. CHEN, S. MA, X. HE, D. XIA, X. JIN, Z. WANG, Y. XIA: "Penpulimab, an IgG1 anti-PD-1 antibody with Fc-engineering to eliminate effector functions and with unique epitope and binding properties", ANNALS OF ONCOLOGY, vol. 32, no. 5, 1 September 2021 (2021-09-01), XP055964899, DOI: 10.1016/j.annonc.2021.08.280
FINCO D., GRIMALDI C., FORT M., WALKER M., KIESSLING A., WOLF B., SALCEDO T., FAGGIONI R., SCHNEIDER A., IBRAGHIMOV A., SCESNEY S.: "Cytokine release assays: Current practices and future directions", CYTOKINE, ACADEMIC PRESS LTD, PHILADELPHIA, PA, US, vol. 66, no. 2, 1 April 2014 (2014-04-01), US , pages 143 - 155, XP055964902, ISSN: 1043-4666, DOI: 10.1016/j.cyto.2013.12.009
XINHUA WANG, MARY MATHIEU, RANDALL J. BREZSKI: "IgG Fc engineering to modulate antibody effector functions", PROTEIN & CELL, SPRINGER ASIA, BEIJING, CN, vol. 9, no. 1, 1 January 2018 (2018-01-01), Beijing, CN , pages 63 - 73, XP055457296, ISSN: 1674-800X, DOI: 10.1007/s13238-017-0473-8
LI B., Z. HUANG, X. PANG, T. ZHONG, C. JIN, N. CHEN, S. MA, X. HE, D. XIA, X. JIN, Z. WANG, Y. XIA: "Penpulimab, an IgG1 anti-PD-1 antibody with Fc-engineering to eliminate effector functions and with unique epitope and binding properties", ANNALS OF ONCOLOGY, vol. 32, no. 5, 1 September 2021 (2021-09-01), XP055964899, DOI: 10.1016/j.annonc.2021.08.280
Attorney, Agent or Firm:
CCPIT PATENT AND TRADEMARK LAW OFFICE (CN)
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