Title:
METHOD FOR INCREASING CELL VIABILITY BY USING DRUG DELIVERY SYSTEM AND ULTRASOUND IRRADIATION, AND ULTRASOUND IRRADIATION APPRATUS USING SAME
Document Type and Number:
WIPO Patent Application WO/2020/091466
Kind Code:
A1
Abstract:
Disclosed are a method for increasing the viability of cells by ultrasound irradiation and an ultrasound irradiation apparatus using same. The method comprises: applying a drug and an epidermal drug delivery system onto the epidermis of a subject; and, with ultrasound parameters each being preset within a certain range, an ultrasound irradiation apparatus irradiating ultrasound onto the epidermis of the subject through an ultrasound generation unit placed within a critical range from the epidermis of the subject, wherein the epidermal drug delivery system induces the formation of cavities, i.e., cavitation around the epidermis of the subject when the ultrasound is irradiated, the ultrasound parameters at least include an ultrasound pressure and an ultrasound duty percentage, the ultrasound pressure is 0.5-1 MPa, and the ultrasound duty percentage is 1-5 %.
Inventors:
KIM CHUL WOO (KR)
PARK DONG HEE (KR)
WON JONG HO (KR)
OH HEA RY (KR)
PARK DONG HEE (KR)
WON JONG HO (KR)
OH HEA RY (KR)
Application Number:
PCT/KR2019/014616
Publication Date:
May 07, 2020
Filing Date:
October 31, 2019
Export Citation:
Assignee:
BIOINFRA LIFE SCIENCE INC (KR)
International Classes:
A61M37/00; A61N7/00
Foreign References:
| US20170216177A1 | 2017-08-03 | |||
| US20080319375A1 | 2008-12-25 | |||
| KR20170104425A | 2017-09-15 |
Other References:
SON, JNNG-WOO.: "Optimization of the Parameter for Transdermal Drug Delivery by Ultrasound with an Ultrasound Contrast Agent and Quantitative Analysis Master's thesis, Department of Biomedical Engineering,", THE GRADUATE SCHOOL OF YONSEI UNIVERSITY, January 2014 (2014-01-01), pages 20 - 28
PARK, D.: "Sonophoresis using ultrasound contrast agents for transdermal drug delivery: an in vivo experimental study", ULTRASOUND IN MED.&BIOL., 2012, pages 642 - 650, XP055705712
"Redensyl-the hair growth galvanizer", COSMETICS BUSINESS, 14 March 2014 (2014-03-14), pages 1 - 3, XP055705714, Retrieved from the Internet [retrieved on 20200209]
PARK, D.: "Sonophoresis using ultrasound contrast agents for transdermal drug delivery: an in vivo experimental study", ULTRASOUND IN MED.&BIOL., 2012, pages 642 - 650, XP055705712
"Redensyl-the hair growth galvanizer", COSMETICS BUSINESS, 14 March 2014 (2014-03-14), pages 1 - 3, XP055705714, Retrieved from the Internet
Attorney, Agent or Firm:
SU INTELLECTUAL PROPERTY (KR)
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