Title:
METHOD FOR INCREASING HALF-LIFE OF BOTULINUM TOXIN TYPE A LIGHT CHAIN PROTEIN
Document Type and Number:
WIPO Patent Application WO/2024/019553
Kind Code:
A1
Abstract:
The present invention relates to: a method for increasing the half-life of a botulinum toxin type A light chain (AUT-BT-LC) protein, the method comprising substituting one or more lysine residues present in the amino acid sequence of the botulinum toxin type A light chain (BT-LC) protein; or a botulinum toxin type A light chain (AUT-BT-LC) protein having an increased half-life. The protein having an increased half-life according to the present invention may be used in a cosmetic composition and a pharmaceutical composition.
Inventors:
KIM MYUNG-SUN (KR)
LIM HYE-YOUNG (KR)
OH SU-KYUNG (KR)
LEE JAE-WOO (KR)
BAE SUNG-RYUL (KR)
CHOI SEUNG-IN (KR)
LIM HYE-YOUNG (KR)
OH SU-KYUNG (KR)
LEE JAE-WOO (KR)
BAE SUNG-RYUL (KR)
CHOI SEUNG-IN (KR)
Application Number:
PCT/KR2023/010454
Publication Date:
January 25, 2024
Filing Date:
July 19, 2023
Export Citation:
Assignee:
UBIPROTEIN CORP (KR)
International Classes:
C12N9/52; A61K8/66; A61K38/48; C07K14/33
Domestic Patent References:
| WO2018203737A2 | 2018-11-08 |
Foreign References:
| US7491799B2 | 2009-02-17 | |||
| US20100273986A1 | 2010-10-28 | |||
| KR102243257B1 | 2021-04-22 |
Other References:
SEN EDANUR, KOTA KRISHNA P., PANCHAL REKHA G., BAVARI SINA, KIRIS ERKAN: "Screening of a Focused Ubiquitin-Proteasome Pathway Inhibitor Library Identifies Small Molecules as Novel Modulators of Botulinum Neurotoxin Type A Toxicity", FRONTIERS IN PHARMACOLOGY, FRONTIERS RESEARCH FOUNDATION, CH, vol. 12, 27 September 2021 (2021-09-27), CH , pages 763950, XP093130740, ISSN: 1663-9812, DOI: 10.3389/fphar.2021.763950
Attorney, Agent or Firm:
LEE, Jong Seung (KR)
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