Title:
A METHOD FOR INCREASING ROMIDEPSIN PRODUCTION FROM FERMENTATION BROTH
Document Type and Number:
WIPO Patent Application WO/2020/139453
Kind Code:
A3
Abstract:
The present invention includes a method to increase romidepsin concentration in a bacteria fermentation media. Romidepsin concentration in a fermentation is increased by adding, for example, copper sulfate. The end resulting romidepsin concentration is increased by at least about two fold as compare to fermentation without copper sulfate.
Inventors:
ODDONE GIAN (US)
BLODGETT JACOB (US)
REVELES RAUL (US)
BLODGETT JACOB (US)
REVELES RAUL (US)
Application Number:
PCT/US2019/058493
Publication Date:
August 06, 2020
Filing Date:
October 29, 2019
Export Citation:
Assignee:
MARRONE BIO INNOVATIONS INC (US)
International Classes:
C12P1/04; C12N1/20
Foreign References:
| US20130236928A1 | 2013-09-12 | |||
| US8691534B2 | 2014-04-08 | |||
| US9624271B2 | 2017-04-18 | |||
| US20150010899A1 | 2015-01-08 |
Other References:
ARAKAKI, A. H. ET AL.: "Optimization of Biomass Production with Copper Bioac cumulation by Yeasts in Submerged Fermentation", BRAZ. ARCH. BIOL. TECHNOL., vol. 54, no. 5, October 2011 (2011-10-01), pages 1027 - 1034, XP055724254
Attorney, Agent or Firm:
SINGLETON, Chainey P. (US)
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