Title:
METHOD FOR INCREASING YIELD OF SPINOSYNS OF SACCHAROPOLYSPORA SPINOSA
Document Type and Number:
WIPO Patent Application WO/2022/262384
Kind Code:
A1
Abstract:
The present invention relates to the field of genetic engineering, and disclosed is a method for increasing the yield of spinosyns of Saccharopolyspora spinosa. The method of the present invention is to overexpress a spnF gene and/or a spnP gene in Saccharopolyspora spinosa. By overexpressing the spnF gene and/or the spnP gene in Saccharopolyspora spinosa, a genetically engineered bacterium of Saccharopolyspora spinosa having high spinosyn yield can be obtained. The present invention finds that the overexpression of the spnF gene and/or the spnP gene can increase the yield of spinosyns of Saccharopolyspora spinosa.
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Inventors:
LIU TIANGANG (CN)
LIU RAN (CN)
DENG ZIXIN (CN)
LIU RAN (CN)
DENG ZIXIN (CN)
Application Number:
PCT/CN2022/085682
Publication Date:
December 22, 2022
Filing Date:
April 08, 2022
Export Citation:
Assignee:
UNIV WUHAN (CN)
International Classes:
C12P19/62; C12N1/20; C12R1/01
Foreign References:
| CN113444659A | 2021-09-28 | |||
| CN102559569A | 2012-07-11 | |||
| CN105506038A | 2016-04-20 | |||
| CN101629203A | 2010-01-20 | |||
| CN105441518A | 2016-03-30 |
Other References:
YE LI-JUAN, LU WANG: "Study on Spinosad Synthetic Genes in Saccharopolyspora spinosa", WORLD NOTES ON ANTIBIOTICS, vol. 30, no. 4, 31 December 2009 (2009-12-31), pages 164 - 170, XP093015985, DOI: 10.13461/j.cnki.wna.004383
Attorney, Agent or Firm:
WUHAN KEHAO INTELLECTUAL PROPERTY ATTORNEYS(SPECIAL GENERAL PARTNERSHIP) (CN)
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