Title:
METHOD FOR INDUCTION OF GENOME INSTABILITY
Document Type and Number:
WIPO Patent Application WO2002092123
Kind Code:
A3
Abstract:
The present invention provides a method for the generation and identification of cell lines that posses genetically unstable genes. More specifically, the present invention provides a method for detecting genes associated in genetic alterations by using specific genes capable of inducing genetic instability such as metastasin 1 gene and their protein product. The products expressed by cells identified as possessing unstable genes are used as therapeutics or therapeutic targets.
Inventors:
ONICHTCHENKO ANATOLI (CA)
ALAKHOV VALERY (CA)
SEMOV ALEXANDRE (CA)
ALAKHOV VALERY (CA)
SEMOV ALEXANDRE (CA)
Application Number:
PCT/IB2002/002833
Publication Date:
January 15, 2004
Filing Date:
May 13, 2002
Export Citation:
Assignee:
SUPRATEK PHARMA INC (CA)
ONICHTCHENKO ANATOLI (CA)
ALAKHOV VALERY (CA)
SEMOV ALEXANDRE (CA)
ONICHTCHENKO ANATOLI (CA)
ALAKHOV VALERY (CA)
SEMOV ALEXANDRE (CA)
International Classes:
C12N15/10; (IPC1-7): C12N5/00; C12N15/11; C12Q1/68; A61K48/00; A61K38/00; C12N15/10
Domestic Patent References:
| WO2000064475A1 | 2000-11-02 | |||
| WO1998049282A1 | 1998-11-05 | |||
| WO1999044063A2 | 1999-09-02 |
Other References:
ENGEBRAATEN OLAV ET AL: "CAPL expression in metastatic cancer cells and inhibition by treatment with antisense oligonucleotide molecules.", CANCER GENE THERAPY, vol. 3, no. 6 CONF. SUPPL., 1996, Fifth International Conference on Gene Therapy of Cancer;San Diego, California, USA; November 14-16, 1996, pages S39, XP009013137, ISSN: 0929-1903
GRIGORIAN MARIAM S ET AL: "The mts1 gene and control of tumor metastasis.", GENE (AMSTERDAM), vol. 135, no. 1-2, 1993, pages 229 - 238, XP001152598, ISSN: 0378-1119
TAKENAGA KEIZO ET AL: "Expression of antisense RNA to S100A4 gene encoding an S100-related calcium-binding protein suppresses metastatic potential of high-metastatic Lewis lung carcinoma cells.", ONCOGENE, vol. 14, no. 3, 1997, pages 331 - 337, XP009013136, ISSN: 0950-9232
KATAYAMA NAOYA ET AL: "The role of S100A4 gene encoding an S100-related calcium-binding protein in human bile duct adenocarcinoma cell lines: Correlation of S100A4 expression and invasive growth in Matrigel Matrix.", INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE, vol. 6, no. 5, November 2000 (2000-11-01), pages 539 - 542, XP009013148, ISSN: 1107-3756
POLLACK J R ET AL: "Genome-wide analysis of DNA copy-number changes using cDNA microarrays", NATURE GENETICS, NATURE AMERICA, NEW YORK, US, vol. 23, no. 1, September 1999 (1999-09-01), pages 41 - 46, XP002221379, ISSN: 1061-4036
DERISI J ET AL: "USE OF A CDNA MICROARRAY TO ANALYSE GENE EXPRESSION PATTERNS IN HUMAN CANCER", NATURE GENETICS, NEW YORK, NY, US, vol. 11, 11 December 1996 (1996-12-11), pages 457 - 460, XP000971491, ISSN: 1061-4036
GRIGORIAN MARIAM S ET AL: "The mts1 gene and control of tumor metastasis.", GENE (AMSTERDAM), vol. 135, no. 1-2, 1993, pages 229 - 238, XP001152598, ISSN: 0378-1119
TAKENAGA KEIZO ET AL: "Expression of antisense RNA to S100A4 gene encoding an S100-related calcium-binding protein suppresses metastatic potential of high-metastatic Lewis lung carcinoma cells.", ONCOGENE, vol. 14, no. 3, 1997, pages 331 - 337, XP009013136, ISSN: 0950-9232
KATAYAMA NAOYA ET AL: "The role of S100A4 gene encoding an S100-related calcium-binding protein in human bile duct adenocarcinoma cell lines: Correlation of S100A4 expression and invasive growth in Matrigel Matrix.", INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE, vol. 6, no. 5, November 2000 (2000-11-01), pages 539 - 542, XP009013148, ISSN: 1107-3756
POLLACK J R ET AL: "Genome-wide analysis of DNA copy-number changes using cDNA microarrays", NATURE GENETICS, NATURE AMERICA, NEW YORK, US, vol. 23, no. 1, September 1999 (1999-09-01), pages 41 - 46, XP002221379, ISSN: 1061-4036
DERISI J ET AL: "USE OF A CDNA MICROARRAY TO ANALYSE GENE EXPRESSION PATTERNS IN HUMAN CANCER", NATURE GENETICS, NEW YORK, NY, US, vol. 11, 11 December 1996 (1996-12-11), pages 457 - 460, XP000971491, ISSN: 1061-4036
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