Title:
METHOD OF INHIBITING PRODUCTION OF OSTEOPONTIN
Document Type and Number:
WIPO Patent Application WO/2005/012259
Kind Code:
A1
Abstract:
A method of inhibiting OPN production, characterized by administering an effective amount of either a pyridazine derivative represented by the general formula (I): (Chemical formula 10) (I) (wherein R1 represents optionally substituted phenyl or pyridyl; R2 represents substituted phenyl; R3 represents hydrogen or optionally substituted phenyl or pyridyl; A represents a single bond, C1-6 linear or branched alkylene, or C2-9 linear or branched alkenylene; and X represents oxygen or sulfur) or a salt of the derivative.
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Inventors:
SAEKI YUKIHIKO (JP)
TABUNOKI YUICHIRO (JP)
KOSHI TOMOYUKI (JP)
TABUNOKI YUICHIRO (JP)
KOSHI TOMOYUKI (JP)
Application Number:
PCT/JP2004/010810
Publication Date:
February 10, 2005
Filing Date:
July 29, 2004
Export Citation:
Assignee:
KOWA CO (JP)
SAEKI YUKIHIKO (JP)
TABUNOKI YUICHIRO (JP)
KOSHI TOMOYUKI (JP)
SAEKI YUKIHIKO (JP)
TABUNOKI YUICHIRO (JP)
KOSHI TOMOYUKI (JP)
International Classes:
A61K31/50; A61K31/501; A61P1/16; A61P9/10; A61P13/04; A61P13/12; A61P31/06; A61P35/00; A61P43/00; C07D237/14; (IPC1-7): C07D237/14; A61K31/50; A61K31/501; A61P1/16; A61P9/10; A61P13/04; A61P13/12; A61P31/06; A61P35/00; A61P43/00; C07D401/06
Domestic Patent References:
| WO1999025697A1 | 1999-05-27 |
Foreign References:
| JP2001526263A | 2001-12-18 | |||
| JP2001522834A | 2001-11-20 | |||
| JP2001521934A | 2001-11-13 | |||
| JP2003063966A | 2003-03-05 | |||
| JP2002511887A | 2002-04-16 |
Other References:
GIULIANI N. ET AL.: "Osteopontin is produced by human multiple myeloma cells", BLOOD, vol. 100, no. 11, 16 November 2002 (2002-11-16), pages 378B, XP002904513
MATSUDA T. ET AL.: "Synthesis and bioactivities of novel 5,6-bis(4-metoxyphenyl)-2H-pyridazin-3-one derivatives: inhibitors of interleukin-1 beta (IL-1 beta) production", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 11, no. 17, 3 September 2001 (2001-09-03), pages 2373 - 2375, XP002904514
See also references of EP 1650195A4
MATSUDA T. ET AL.: "Synthesis and bioactivities of novel 5,6-bis(4-metoxyphenyl)-2H-pyridazin-3-one derivatives: inhibitors of interleukin-1 beta (IL-1 beta) production", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 11, no. 17, 3 September 2001 (2001-09-03), pages 2373 - 2375, XP002904514
See also references of EP 1650195A4
Attorney, Agent or Firm:
The, Patent Corporate Body Aruga Patent Office (3-6 NIHONBASHININGYOCHO 1-CHOME, CHUO-K, Tokyo 13, JP)
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