Title:
METHOD AND KIT FOR QUANTIFYING LIPOPROTEIN CHOLESTEROL
Document Type and Number:
WIPO Patent Application WO/2021/246426
Kind Code:
A1
Abstract:
Provided are: a method for using an autoanalyzer to quantify lipoprotein cholesterol in two steps without pre-treating a sample wherein the natural coloration of a reagent during storage is inhibited; a quantification kit for use in this method; and a preparation method. The kit for quantifying lipoprotein cholesterol in a sample to be tested is used in the method for quantifying the lipoprotein cholesterol in two steps and comprises (1) a first reagent composition which contains cholesterol esterase, cholesterol oxidase, cholesterol esterase, and cholesterol oxidase and which guides lipoprotein cholesterol that is not to be measured to the outside of the reaction system and (2) a second reagent composition which is for quantifying lipoprotein cholesterol to be measured, said kit being characterized in that: each of at least a coupler, an iron complex, peroxidase, catalase, a hydrogen donor, and a surfactant are contained in the first reagent composition and/or the second reagent composition; the coupler and the hydrogen donor are not contained in the same reagent composition; and the coupler, the iron complex, and the peroxidase do not coexist in the same reagent composition among the first reagent composition and the second reagent composition.
Inventors:
ITOH YASUKI (JP)
Application Number:
PCT/JP2021/020923
Publication Date:
December 09, 2021
Filing Date:
June 02, 2021
Export Citation:
Assignee:
DENKA COMPANY LTD (JP)
International Classes:
C12Q1/26; C12Q1/28; C12Q1/30; C12Q1/44
Domestic Patent References:
| WO2009048143A1 | 2009-04-16 | |||
| WO2021049518A1 | 2021-03-18 |
Foreign References:
| JP2019174257A | 2019-10-10 | |||
| JP3164829B2 | 2001-05-14 | |||
| JP3058602B2 | 2000-07-04 | |||
| JP5706418B2 | 2015-04-22 | |||
| JP6054051B2 | 2016-12-27 | |||
| JP2020096248A | 2020-06-18 |
Other References:
MIYAMOTO IKUMI: "Basic Evaluation of LDL-C Reagent-KL", SYSMEX JOURNAL WEB, vol. 8, no. 1, 1 January 2007 (2007-01-01), pages 1 - 7, XP093011516
JAMA, vol. 260, 1988, pages 1917 - 21
"HANDBOOK OF LIPOPROTEIN TESTING", vol. AVI, 2002, AACC PRESS, pages: 15 - 16
ATHEROSCLEROSIS, vol. 106, 1994, pages 241 - 253
ATHEROSCLEROSIS, vol. 83, 1990, pages 59
BIOCHEMICAL MEDICINE AND METABOLIC BIOLOGY, vol. 46, 1991, pages 329 - 343
J. LIPID RESEARCH, vol. 3, no. 8, 1997, pages 1204 - 16
ANN. CLIN. BIOCHEM., vol. 56, 2019, pages 123 - 132
J. APPLIED LABORATORY MEDICINE, vol. 3, 2018, pages 26 - 36
See also references of EP 4155413A4
JAMA, vol. 260, 1988, pages 1917 - 21
"HANDBOOK OF LIPOPROTEIN TESTING", vol. AVI, 2002, AACC PRESS, pages: 15 - 16
ATHEROSCLEROSIS, vol. 106, 1994, pages 241 - 253
ATHEROSCLEROSIS, vol. 83, 1990, pages 59
BIOCHEMICAL MEDICINE AND METABOLIC BIOLOGY, vol. 46, 1991, pages 329 - 343
J. LIPID RESEARCH, vol. 3, no. 8, 1997, pages 1204 - 16
ANN. CLIN. BIOCHEM., vol. 56, 2019, pages 123 - 132
J. APPLIED LABORATORY MEDICINE, vol. 3, 2018, pages 26 - 36
See also references of EP 4155413A4
Attorney, Agent or Firm:
HIRAKI & ASSOCIATES (JP)
Download PDF:
Previous Patent: FOAM GENERATOR AND FOAM GENERATION METHOD
Next Patent: ELECTRO-ACOUSTIC TRANSDUCER DIAPHRAGM
Next Patent: ELECTRO-ACOUSTIC TRANSDUCER DIAPHRAGM