Title:
METHOD OF LARGE SCALE PRODUCTION OF HEPATITIS A VIRUS
Document Type and Number:
WIPO Patent Application WO2003049767
Kind Code:
A3
Abstract:
The present invention provides methods of large scale production of Hepatitis A Virus (HAV) on VERO cells bound to microcarrier. The invention also provides for methods of isolation of HAV from the cell culture supernatant of HAV infected VERO cells.
Inventors:
MEYER HEIDI (DE)
REITER MANFRED (AT)
MUNDT WOLFGANG (AT)
BARRETT NOEL (AT)
DORNER FRIEDRICH (AT)
REITER MANFRED (AT)
MUNDT WOLFGANG (AT)
BARRETT NOEL (AT)
DORNER FRIEDRICH (AT)
Application Number:
PCT/EP2002/014012
Publication Date:
March 11, 2004
Filing Date:
December 10, 2002
Export Citation:
Assignee:
BAXTER HEALTHCARE SA (CH)
MEYER HEIDI (DE)
REITER MANFRED (AT)
MUNDT WOLFGANG (AT)
BARRETT NOEL (AT)
DORNER FRIEDRICH (AT)
MEYER HEIDI (DE)
REITER MANFRED (AT)
MUNDT WOLFGANG (AT)
BARRETT NOEL (AT)
DORNER FRIEDRICH (AT)
International Classes:
A61K39/29; C12N5/07; C12N5/071; C12N7/01; C12N7/02; (IPC1-7): C12N7/02; C07K14/10; C12N5/00
Domestic Patent References:
| WO1996015231A2 | 1996-05-23 | |||
| WO1991009935A1 | 1991-07-11 | |||
| WO2001011065A2 | 2001-02-15 |
Foreign References:
| US6194210B1 | 2001-02-27 | |||
| US4783407A | 1988-11-08 |
Other References:
WIDELL A ET AL: "A microcarrier cell culture system for large scale production of hepatitis A virus.", JOURNAL OF VIROLOGICAL METHODS. NETHERLANDS FEB 1984, vol. 8, no. 1-2, February 1984 (1984-02-01), pages 63 - 71, XP001117820, ISSN: 0166-0934
KISTNER O ET AL: "Development of a mammalian cell (Vero) derived candidate influenza virus vaccine.", VACCINE. ENGLAND 1998 MAY-JUN, vol. 16, no. 9-10, May 1998 (1998-05-01), pages 960 - 968, XP004122292, ISSN: 0264-410X
KISTNER O ET AL: "Development of a mammalian cell (Vero) derived candidate influenza virus vaccine.", VACCINE. ENGLAND 1998 MAY-JUN, vol. 16, no. 9-10, May 1998 (1998-05-01), pages 960 - 968, XP004122292, ISSN: 0264-410X
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