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Title:
METHOD OF MAKING FLUORINE GROUP-CONTAINING AROMATIC COMPOUNDS
Document Type and Number:
WIPO Patent Application WO/2017/167756
Kind Code:
A1
Abstract:
The invention pertains to a method of making an aromatic compound comprising a fluorine-containing group, the method comprising the following steps: Step (1): providing an aromatic compound comprising at least one aromatic ring comprising sp2-hybridized carbon atoms [compound (Ar)], and a nitrile compound comprising at least one nitrile group (-CN) bound to a fluorine-containing group (group Rf) [nitrile (F)]; Step (2): reacting the nitrile (F) with compound (Ar) under electrophilic substitution conditions followed by hydrolytic conditions so as to generate a ketone derivative comprising a group -C(O)-Rf covalently bound to a sp2-hybridized carbon atom of an aromatic ring, wherein Rf has the meaning as indicated above [ketone (Ar)]; and Step (3): reacting ketone (Ar) with a reducing agent effective in reducing carbonyl group -C(O)-, so as to obtain an aromatic compound comprising a group -CH2-Rf covalently bound to a sp2-hybridized carbon atom of an aromatic ring.

Inventors:
WLASSICS IVAN DIEGO (IT)
MILLEFANTI STEFANO (IT)
Application Number:
PCT/EP2017/057319
Publication Date:
October 05, 2017
Filing Date:
March 28, 2017
Export Citation:
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Assignee:
SOLVAY SPECIALTY POLYMERS IT (IT)
International Classes:
C07C43/12; C07C17/00; C08G65/00
Domestic Patent References:
WO2007075804A12007-07-05
WO1989002884A11989-04-06
WO2012138457A12012-10-11
Foreign References:
US3810874A1974-05-14
US4647413A1987-03-03
US5545693A1996-08-13
Other References:
KEMP, D.S. ET AL.: "Chimica Organica. : N. Zanichelli", 1983, article "Ch. 3,4,6,7"
CHAMBERS, R. ET AL.: "Fluorine in Organic Chemistry", 2004, BLACKWELL PUBLISHING, article "Chapt. 4"
Attorney, Agent or Firm:
BENVENUTI, Federica (310, 1120 BRUXELLES, BE)
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