Title:
METHOD FOR MANUFACTURING 3-(ALKYL SULFONYL)PYRIDINE-2-CARBOXYLIC ACID
Document Type and Number:
WIPO Patent Application WO/2015/199006
Kind Code:
A1
Abstract:
A compound that can be represented by formula (7) or a salt thereof can be manufactured via the following steps: a step in which a compound that can be represented by formula (1-S) (in which R1 represents a C1
-
8 straight-chain alkyl group and X represents a halogen atom) and a compound that can be represented by formula (2) (in which R2 represents a C1
-
8 straight-chain alkyl group and M2 represents either a hydrogen atom or an alkali metal) are reacted, yielding a compound that can be represented by formula (3-S) (in which R1, R2, and X have the aforementioned meanings); a step in which the compound that can be represented by formula (3-S) is reacted with hydrogen peroxide in the presence of a tungsten catalyst and an acid, yielding a compound that can be represented by formula (6-S) (in which X and R2 have the abovementioned meanings) or a salt thereof; and a step in which the compound that can be represented by formula (6-S) or a salt thereof is reduced in the presence of a base and a heterogeneous transition-metal catalyst, yielding the compound that can be represented by formula (7) (in which R2 has the abovementioned meaning) or a salt thereof.
(1-S)
(2) R2SM2
(3-S)
(6-S)
(7)
Inventors:
KIMURA TAKAHIRO (JP)
MAEHATA RYOTA (JP)
MAEHATA RYOTA (JP)
Application Number:
PCT/JP2015/067827
Publication Date:
December 30, 2015
Filing Date:
June 22, 2015
Export Citation:
Assignee:
SUMITOMO CHEMICAL CO (JP)
International Classes:
C07D213/78; C07B61/00; C07D213/79; C07D213/803; C07D213/81
Foreign References:
| JP2014005263A | 2014-01-16 | |||
| JP2009529577A | 2009-08-20 | |||
| CH657124A5 | 1986-08-15 |
Other References:
BLANK B. ET AL.: "Mercaptopyridinecarboxylic Acids, Synthesis and Hypoglycemic Activity", JOURNAL OF MEDICINAL CHEMISTRY, vol. 17, no. 10, 1974, pages 1065 - 1071, XP002158204, ISSN: 0022-2623
BLANK B. ET AL.: "Mercapto Heterocyclic Carboxylic Acids, Analogues of 3- Mercaptopicolinic Acid", JOURNAL OF MEDICINAL CHEMISTRY, vol. 20, no. 4, 1977, pages 572 - 576, XP008041213, ISSN: 0022-2623
See also references of EP 3162795A4
BLANK B. ET AL.: "Mercapto Heterocyclic Carboxylic Acids, Analogues of 3- Mercaptopicolinic Acid", JOURNAL OF MEDICINAL CHEMISTRY, vol. 20, no. 4, 1977, pages 572 - 576, XP008041213, ISSN: 0022-2623
See also references of EP 3162795A4
Attorney, Agent or Firm:
NAKAYAMA, Tohru et al. (JP)
Nakayama δΊ¨ (JP)
Nakayama δΊ¨ (JP)
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