Title:
METHOD OF MANUFACTURING GADOBUTROL
Document Type and Number:
WIPO Patent Application WO/2020/040617
Kind Code:
A1
Abstract:
The present invention provides a novel method for producing gadobutrol of high purity or a hydrate thereof. Unlike the conventional method for synthesizing gadobutrol, the production method of the present invention can simplify the process by forming a gadolinium complex in-situ without purification of butrol intermediates, and can eliminate the resin purification process. In addition, the production method of the present invention can produce gadobutrol of high purity or a hydrate thereof in a high yield merely by a simple process as described above, and thus can be beneficially used for high-throughput production.
Inventors:
BYEON CHANGHO (KR)
YOON HOEJIN (KR)
KIM MOONSU (KR)
JEONG SEONGSU (KR)
PARK JONGMOON (KR)
LEE JUNWON (KR)
WOO SEOKHUN (KR)
CHANG SUN KI (KR)
YOON HOEJIN (KR)
KIM MOONSU (KR)
JEONG SEONGSU (KR)
PARK JONGMOON (KR)
LEE JUNWON (KR)
WOO SEOKHUN (KR)
CHANG SUN KI (KR)
Application Number:
PCT/KR2019/010802
Publication Date:
February 27, 2020
Filing Date:
August 23, 2019
Export Citation:
Assignee:
ST PHARM CO LTD (KR)
International Classes:
C07D257/02
Foreign References:
| KR20160079460A | 2016-07-06 | |||
| US20170106103A1 | 2017-04-20 | |||
| KR20150083721A | 2015-07-20 | |||
| KR20160032872A | 2016-03-25 | |||
| KR20140035911A | 2014-03-24 | |||
| KR101653064B1 | 2016-09-09 |
Other References:
INORG. CHEM., vol. 36, 1997, pages 6086 - 6093
See also references of EP 3819294A4
See also references of EP 3819294A4
Attorney, Agent or Firm:
AHN, So Young (KR)
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