Title:
METHOD AND MEANS FOR THE DETERMINATION OF DEFINED STATES OR MODIFICATIONS IN THE MUCUS OF THE UTERUS OR IN THE EPITHELIUM OF OTHER ORGANS
Document Type and Number:
WIPO Patent Application WO2004109292
Kind Code:
A3
Abstract:
The invention relates to a method and means for the determination of defined states or modifications in the mucus of the uterus or in the epithelium of other organs, especially for the diagnosis of pregnancy and diagnosis of embryo-implantation. In a biological sample, the concentration of human endometrial chorionic gonadotropin (eßhCG/ehCG) and/or non-trophoblastic hCG (hCG type I, ß6, ß7) is determined in a specific manner, wherein the hCG (hCG type II, tßhCG) which is to be trophoblastic is different. The invention also relates to the sequence of the ß sub-unit of human endometrial chorionic gonadotropin of eßhCG, and anti-bodies which are specifically different from eßhCG/ehCG and hCG type II, tßhCG, and to a test kit for carrying out said method.
Inventors:
ALEXANDER HENRY (DE)
ZIMMERMANN GEROLF (DE)
ZIMMERMANN GEROLF (DE)
Application Number:
PCT/DE2004/001210
Publication Date:
May 18, 2006
Filing Date:
June 04, 2004
Export Citation:
Assignee:
UNIV LEIPZIG (DE)
ALEXANDER HENRY (DE)
ZIMMERMANN GEROLF (DE)
ALEXANDER HENRY (DE)
ZIMMERMANN GEROLF (DE)
International Classes:
C07K14/59; C07K16/26; G01N33/76; (IPC1-7): G01N33/76; C07K14/59; C07K16/26
Domestic Patent References:
| WO2004058999A2 | 2004-07-15 |
Foreign References:
| US6514708B2 | 2003-02-04 | |||
| EP1321768A1 | 2003-06-25 |
Other References:
BERGER P ET AL: "THE ISOBM TD-7 WORKSHOP ON HCG AND RELATED MOLECULES", TUMOR BIOLOGY, KARGER, BASEL, CH, vol. 23, no. 1, January 2002 (2002-01-01), pages 1 - 38, XP009032819, ISSN: 1010-4283
LUNDIN M ET AL: "Tissue expression of human chorionic gonadotropin beta predicts outcome in colorectal cancer: A comparison with serum expression", INTERNATIONAL JOURNAL OF CANCER, NEW YORK, NY, US, vol. 95, no. 1, 20 January 2001 (2001-01-20), pages 18 - 22, XP002286298, ISSN: 0020-7136
BELLET D ET AL: "MALIGNANT TRANSFORMATION OF NONTROPHOBLASTIC CELLS IS ASSOCIATED WITH THE EXPRESSION OF CHORIONIC GONADOTROPIN BETA GENES NORMALLY TRANSCRIBED IN TROPHOBLASTIC CELLS", CANCER RESEARCH, AMERICAN ASSOCIATION FOR CANCER RESEARCH, BALTIMORE, MD, US, vol. 57, 1 February 1997 (1997-02-01), pages 516 - 523, XP002040116, ISSN: 0008-5472
TAKAHASHI K ET AL: "CLINICAL USEFULNESS OF DETERMINATION OF ESTRADIOL LEVEL IN THE MENSTRUAL BLOOD FOR PATIENTS WITH ENDOMETRIOSIS", ACTA OBSTETRICA ET GYNAECOLOGICA JAPONICA - NIHON SANKA FUJINKA GAKKAI ZASSHI, XX, XX, vol. 41, no. 11, November 1989 (1989-11-01), pages 1849 - 1850, XP001098384, ISSN: 0300-9165
LUNDIN M ET AL: "Tissue expression of human chorionic gonadotropin beta predicts outcome in colorectal cancer: A comparison with serum expression", INTERNATIONAL JOURNAL OF CANCER, NEW YORK, NY, US, vol. 95, no. 1, 20 January 2001 (2001-01-20), pages 18 - 22, XP002286298, ISSN: 0020-7136
BELLET D ET AL: "MALIGNANT TRANSFORMATION OF NONTROPHOBLASTIC CELLS IS ASSOCIATED WITH THE EXPRESSION OF CHORIONIC GONADOTROPIN BETA GENES NORMALLY TRANSCRIBED IN TROPHOBLASTIC CELLS", CANCER RESEARCH, AMERICAN ASSOCIATION FOR CANCER RESEARCH, BALTIMORE, MD, US, vol. 57, 1 February 1997 (1997-02-01), pages 516 - 523, XP002040116, ISSN: 0008-5472
TAKAHASHI K ET AL: "CLINICAL USEFULNESS OF DETERMINATION OF ESTRADIOL LEVEL IN THE MENSTRUAL BLOOD FOR PATIENTS WITH ENDOMETRIOSIS", ACTA OBSTETRICA ET GYNAECOLOGICA JAPONICA - NIHON SANKA FUJINKA GAKKAI ZASSHI, XX, XX, vol. 41, no. 11, November 1989 (1989-11-01), pages 1849 - 1850, XP001098384, ISSN: 0300-9165
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