Title:
METHOD FOR MEASURING HUMAN INSULIN AND MEASUREMENT REAGENT
Document Type and Number:
WIPO Patent Application WO/2011/078384
Kind Code:
A1
Abstract:
Provided are an antibody specific to human insulin, which enables accurate measurement of human insulin without being affected by swine insulin, and a measurement method and a measurement reagent using said antibody.
By using of a monoclonal antibody, which reacts specifically with human insulin but not with swine insulin, together with another anti-human insulin antibody, a measurement method and a measurement reagent, whereby human insulin can be specifically measured, can be provided.
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Inventors:
SHIMIZU TOMO (JP)
KONDOU JUNICHI (JP)
NAKAMURA YASUSHI (JP)
YAMAMOTO MITSUAKI (JP)
KONDOU JUNICHI (JP)
NAKAMURA YASUSHI (JP)
YAMAMOTO MITSUAKI (JP)
Application Number:
PCT/JP2010/073633
Publication Date:
June 30, 2011
Filing Date:
December 27, 2010
Export Citation:
Assignee:
SEKISUI MEDICAL CO LTD (JP)
SHIMIZU TOMO (JP)
KONDOU JUNICHI (JP)
NAKAMURA YASUSHI (JP)
YAMAMOTO MITSUAKI (JP)
SHIMIZU TOMO (JP)
KONDOU JUNICHI (JP)
NAKAMURA YASUSHI (JP)
YAMAMOTO MITSUAKI (JP)
International Classes:
C07K16/26; G01N33/53; G01N33/543; G01N33/545; G01N33/577; C12P21/08
Foreign References:
| JPH01148962A | 1989-06-12 | |||
| JPH03118472A | 1991-05-21 | |||
| JPS60188327A | 1985-09-25 | |||
| JP2010062261W | 2010-07-21 |
Other References:
MIRZA I.H. ET AL.: "Antigenicity of the carboxyl terminus of insulin: Isolation of human insulin-specific monoclonal antibodies", IMMUNOLOGY, vol. 65, 1988, pages 43 - 46, XP009169066
TADASHI KOBAYASHI ET AL.: "Recent progress in laboratory tests of endocrine function. Measurement and clinical significance of insulin antibody and anti-insulin receptor antibody", THE JAPANESE JOURNAL OF CLINICAL PATHOLOGY, vol. 33, 1985, pages 513 - 518, XP009169065
SASAKI, ATSUKO ET AL.: "Monoclonal antibodies identify tertiary structure differences in insulin molecules", JIKEIKAI MED J, vol. 34, 1987, pages 337 - 357, XP009169061
See also references of EP 2518084A4
CLINICAL CHEMISTRY, vol. 47, no. 3, 2001, pages 602 - 5
CLINICAL LABORATORY, vol. 49, no. 3-4, 2003, pages 113 - 21
CLINICAL CHEMISTRY, vol. 50, no. 1, 2004, pages 257 - 9
"Antibodies, A Laboratory Manual", 1988, COLD SPRING HARBOR LABORATORY PRESS
TADASHI KOBAYASHI ET AL.: "Recent progress in laboratory tests of endocrine function. Measurement and clinical significance of insulin antibody and anti-insulin receptor antibody", THE JAPANESE JOURNAL OF CLINICAL PATHOLOGY, vol. 33, 1985, pages 513 - 518, XP009169065
SASAKI, ATSUKO ET AL.: "Monoclonal antibodies identify tertiary structure differences in insulin molecules", JIKEIKAI MED J, vol. 34, 1987, pages 337 - 357, XP009169061
See also references of EP 2518084A4
CLINICAL CHEMISTRY, vol. 47, no. 3, 2001, pages 602 - 5
CLINICAL LABORATORY, vol. 49, no. 3-4, 2003, pages 113 - 21
CLINICAL CHEMISTRY, vol. 50, no. 1, 2004, pages 257 - 9
"Antibodies, A Laboratory Manual", 1988, COLD SPRING HARBOR LABORATORY PRESS
Attorney, Agent or Firm:
MOEGI PATENT OFFICE (JP)
Patent business corporation It burns and is ぎ特許事務所. (JP)
Patent business corporation It burns and is ぎ特許事務所. (JP)
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