Title:
METHOD OF MODULATING THE PROLIFERATION OF MEDULLARY THYROID CARCINOMA CELLS
Document Type and Number:
WIPO Patent Application WO2002070555
Kind Code:
A3
Abstract:
The present invention is directed to a method of decreasing the rate of proliferation of medullary thyroid carcinoma cells which comprises contacting medullary thyroid carcinoma cells with one or more SSTR2 agonist.
Inventors:
DEGLI UBERTI ETTORE CIRO (IT)
ZATELLI MARIA CHIARA (IT)
CULLER MICHAEL DEWITT (US)
ZATELLI MARIA CHIARA (IT)
CULLER MICHAEL DEWITT (US)
Application Number:
PCT/US2002/006729
Publication Date:
December 04, 2003
Filing Date:
March 06, 2002
Export Citation:
Assignee:
IL CONSORZIO FERRARA RICHERCHE (IT)
SOD CONSEILS RECH APPLIC (FR)
DEGLI UBERTI ETTORE CIRO (IT)
ZATELLI MARIA CHIARA (IT)
CULLER MICHAEL DEWITT (US)
SOD CONSEILS RECH APPLIC (FR)
DEGLI UBERTI ETTORE CIRO (IT)
ZATELLI MARIA CHIARA (IT)
CULLER MICHAEL DEWITT (US)
International Classes:
A61K38/00; A61K38/08; A61K38/31; G01N33/48; A61K45/00; A61K51/00; A61P35/00; A61P35/04; A61P43/00; C07K7/06; C07K7/64; C12N5/07; C12N5/077; C12N5/0783; C12N5/09; C12Q1/02; G01N33/68; (IPC1-7): C07K14/655; A61K38/31; A61P35/00
Domestic Patent References:
| WO2001000676A1 | 2001-01-04 |
Other References:
LARS KÖLBY ET AL.: "Somatostatin receptor subtypes, octreotide scintigraphy, and clinical response to octreotide treatment in patients with neuroendocrine tumors", WORLD J. SURG., vol. 22, no. 7, - July 1998 (1998-07-01), pages 679 - 683, XP002236312
REUBI J.C. ET AL.: "Expression and localization of somatostatin receptor SSTR1, SSTR2, and SSTR3 messenger RNAs in primary human tumors using in Situ hybridization", CANCER RESEARCH, vol. 54, no. 13, - 1 July 1994 (1994-07-01), pages 3455 - 3459, XP001146326
MATO E. ET AL.: "Somatostatin and somatostatin receptor subtype gene expression in medullary thyroid carcinoma", THE JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, vol. 83, no. 7, - July 1998 (1998-07-01), pages 2417 - 2420, XP009007993
AHLMAN H., ET AL.: "The relevance of somatostatin receptors in thyroid neoplasia", YALE JOURNAL OF BIOLOGY AND MEDICINE, vol. 70, no. 5/6, September 1997 (1997-09-01) - December 1997 (1997-12-01), pages 523 - 533, XP009008013
L. BERNÀ ET AL.: "Use of somatostatin analogue scintigraphy in the localization of recurrent medullary thyroid carcinoma", EUROPEAN JOURNAL OF NUCLEAR MEDICINE, vol. 25, no. 11, November 1998 (1998-11-01), pages 1482 - 1488, XP002236313
N. KIMURA ET AL.: "Immunochemical expression of somatostatin type 2a receptor in neuroendocrine tumors", CLINICAL CANCER RESEARCH: AN OFFICIAL JOURNAL OF THE AMERICAN ASSOCIATION FOR CANCER RESEARCH, vol. 5, no. 11, November 1999 (1999-11-01), pages 3483 - 3487, XP001146327
REUBI J.C. ET AL.: "Expression and localization of somatostatin receptor SSTR1, SSTR2, and SSTR3 messenger RNAs in primary human tumors using in Situ hybridization", CANCER RESEARCH, vol. 54, no. 13, - 1 July 1994 (1994-07-01), pages 3455 - 3459, XP001146326
MATO E. ET AL.: "Somatostatin and somatostatin receptor subtype gene expression in medullary thyroid carcinoma", THE JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, vol. 83, no. 7, - July 1998 (1998-07-01), pages 2417 - 2420, XP009007993
AHLMAN H., ET AL.: "The relevance of somatostatin receptors in thyroid neoplasia", YALE JOURNAL OF BIOLOGY AND MEDICINE, vol. 70, no. 5/6, September 1997 (1997-09-01) - December 1997 (1997-12-01), pages 523 - 533, XP009008013
L. BERNÀ ET AL.: "Use of somatostatin analogue scintigraphy in the localization of recurrent medullary thyroid carcinoma", EUROPEAN JOURNAL OF NUCLEAR MEDICINE, vol. 25, no. 11, November 1998 (1998-11-01), pages 1482 - 1488, XP002236313
N. KIMURA ET AL.: "Immunochemical expression of somatostatin type 2a receptor in neuroendocrine tumors", CLINICAL CANCER RESEARCH: AN OFFICIAL JOURNAL OF THE AMERICAN ASSOCIATION FOR CANCER RESEARCH, vol. 5, no. 11, November 1999 (1999-11-01), pages 3483 - 3487, XP001146327
Download PDF: