Title:
METHOD OF MODULATING VEGF AND USES THEREOF
Document Type and Number:
WIPO Patent Application WO/2023/134658
Kind Code:
A1
Abstract:
The invention provides for a composition, which in particular comprising a fusion molecule comprising a least one DNA binding protein and at least one modulator of gene expression, wherein the fusion molecule is targeted to a genomic region near a VEGF gene and/or within a VEGF regulatory element and the at least one modulator of gene expression provides a modification of at least one nucleotide near the VEGF gene and/or within a VEGF regulatory element. The invention also provides methods of reduction or elimination of VEGF gene products in vivo and uses thereof.
Inventors:
ZHOU CHANGYANG (CN)
SUN YIDI (CN)
MAO SHAOSHUAI (CN)
PENG WENBO (CN)
SUN YIDI (CN)
MAO SHAOSHUAI (CN)
PENG WENBO (CN)
Application Number:
PCT/CN2023/071521
Publication Date:
July 20, 2023
Filing Date:
January 10, 2023
Export Citation:
Assignee:
EPIGENIC THERAPEUTICS INC (CN)
International Classes:
A61P27/02; C12N15/113; C07K14/515; C12N9/22
Domestic Patent References:
| WO2021243105A1 | 2021-12-02 |
Foreign References:
| CN111748583A | 2020-10-09 | |||
| US20030044404A1 | 2003-03-06 |
Other References:
SHI MENGRAN, SHEN ZONGYI, ZHANG NAN, WANG LUYAO, YU CHANGYUAN, YANG ZHAO: "CRISPR/Cas9 technology in disease research and therapy: A review", SHENG WU GONG CHENG XUE BAO = CHINESE JOURNAL OF BIOTECHNOLOGY, vol. 37, no. 4, 25 April 2021 (2021-04-25), pages 1205 - 1228, XP093079699, DOI: 10.13345/j.cjb.200401
LING SIKAI; YANG SHIQI; HU XINDE; YIN DI; DAI YAO; QIAN XIAOQING; WANG DAWEI; PAN XIAOYONG; HONG JIAXU; SUN XIAODONG; YANG HUI; PA: "Lentiviral delivery of co-packaged Cas9 mRNA and a Vegfa-targeting guide RNA prevents wet age-related macular degeneration in mice", NATURE BIOMEDICAL ENGINEERING, NATURE PUBLISHING GROUP UK, LONDON, vol. 5, no. 2, 1 January 1900 (1900-01-01), London , pages 144 - 156, XP037367395, DOI: 10.1038/s41551-020-00656-y
LING SIKAI; YANG SHIQI; HU XINDE; YIN DI; DAI YAO; QIAN XIAOQING; WANG DAWEI; PAN XIAOYONG; HONG JIAXU; SUN XIAODONG; YANG HUI; PA: "Lentiviral delivery of co-packaged Cas9 mRNA and a Vegfa-targeting guide RNA prevents wet age-related macular degeneration in mice", NATURE BIOMEDICAL ENGINEERING, NATURE PUBLISHING GROUP UK, LONDON, vol. 5, no. 2, 1 January 1900 (1900-01-01), London , pages 144 - 156, XP037367395, DOI: 10.1038/s41551-020-00656-y
Attorney, Agent or Firm:
SHANGHAI DIANSHI PARTNERS, P.C. (CN)
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